Bovine FGF-2 Recombinant Protein (RPPB0210)

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SKU:
RPPB0210
Product type:
Recombinant Protein
Size:
50ug
Species:
Bovine
Target:
FGF-2
Synonyms:
HBGH-2
Synonyms:
HBGF-2
Synonyms:
Prostatropin
Synonyms:
FGF-2
Source:
Escherichia Coli
Uniprot:
P03969
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Description

Product Name:Bovine FGF-2 Recombinant Protein
Product Code:RPPB0210
Size:50µg
Species:Bovine
Target:FGF-2
Synonyms:HBGH-2, HBGF-2, Prostatropin, FGF-2, FGB-b.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The FGF-b Bovine was lyophilized from a concentrated (1mg/ml) sterile solution containing 1% HSA.
Solubility:It is recommended to reconstitute the lyophilized Fibroblast Growth Factor-2 Bovine Recombinant in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Fibroblast Growth Factor 2 Bovine although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FGF-b Bovine Recombinant should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ala-Ala-Gly-Ser
Biological Activity:The ED50, measured in a mitogenic assay using quiescent NR6R-3T3 fibroblasts was found to be <0.1ng/ml, corresponding to a specific activity of 3 x 106 Units/mg.

FGF-basic is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from AUG and non-AUG (CUG) initiation codons resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.

FGF-2 Bovine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 155 amino acids and having a molecular mass of 17250 Dalton. The Fibroblast Growth Factor 2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis.
UniProt Protein Details:
NCBI Summary:
UniProt Code:P03969
NCBI GenInfo Identifier:122741
NCBI Gene ID:281161
NCBI Accession:P03969.1
UniProt Secondary Accession:P03969
UniProt Related Accession:P03969
Molecular Weight:17,250 Da
NCBI Full Name:Fibroblast growth factor 2
NCBI Synonym Full Names:
NCBI Official Symbol:FGF2  
NCBI Official Synonym Symbols:BFGF; FGF-2; HBGF-2  
NCBI Protein Information:fibroblast growth factor 2
UniProt Protein Name:Fibroblast growth factor 2
UniProt Synonym Protein Names:Basic fibroblast growth factor; bFGF
Protein Family:Fibroblast growth factor
UniProt Gene Name:FGF2  
UniProt Entry Name:FGF2_BOVIN
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