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  • ๋ธ”๋กœ๊ทธ๋ฅผ ํ•˜๋‹ค
  • neurodegenerative diseases

๋ธ”๋กœ๊ทธ๋ฅผ ํ•˜๋‹ค

Exploring the Role of Gut Fungi in Neurodegenerative Diseases

์‹ ๊ฒฝํ‡ดํ–‰์„ฑ ์งˆํ™˜์—์„œ ์žฅ๋‚ด ๊ณฐํŒก์ด์˜ ์—ญํ•  ํƒ๊ตฌ ์น˜๋งค๋ฅผ ํฌํ•จํ•œ ์‹ ๊ฒฝํ‡ดํ–‰์„ฑ ์งˆํ™˜์€ ์ „ ์„ธ๊ณ„ ๊ฑด๊ฐ•์— ์ค‘๋Œ€ํ•œ ๋„์ „ ๊ณผ์ œ๊ฐ€ ๋˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ์ตœ๊ทผ ์—ฐ๊ตฌ๋Š” ๋ฏธ์ƒ๋ฌผ๊ตฐ์ง‘ ๋‚ด์—์„œ ์žฅ๋‚ด ๊ณฐํŒก์ด๊ฐ€ ์ˆจ๊ฒจ์ง„ ์—ญํ• ์„ ํ•˜๊ณ  ์žˆ์Œ์„ ๋ฐํ˜€๋‚ด๊ธฐ ์‹œ์ž‘ํ–ˆ์œผ๋ฉฐ, ์ด๋Ÿฌํ•œ ๋ฏธ์ƒ๋ฌผ ์„ฑ๋ถ„์ด ์ด๋Ÿฌํ•œ ์‡ ์•ฝํ•œ ์ƒํƒœ์˜ ๋ฐœ๋ณ‘ ๋ฐ ์ง„ํ–‰์— ์˜ํ–ฅ์„ ๋ฏธ์น  ์ˆ˜ ์žˆ์Œ์„ ์‹œ์‚ฌํ•ฉ๋‹ˆ๋‹ค. ์ด ๊ธฐ์‚ฌ๋Š” ์‹ ๊ฒฝํ‡ดํ–‰์„ฑ ์งˆํ™˜์—์„œ ์žฅ๋‚ด ๊ณฐํŒก์ด์˜ ์ค‘์š”ํ•˜์ง€๋งŒ ์ข…์ข… ๊ฐ„๊ณผ๋˜๋Š” ์—ญํ• ์„ ํƒ๊ตฌํ•˜๋ฉฐ, ๊ทธ ์ƒ๋ฌผํ•™์  ๋ฉ”์ปค๋‹ˆ์ฆ˜๊ณผ ์ธ๊ฐ„ ๊ฑด๊ฐ•์— ๋ฏธ์น˜๋Š” ์˜ํ–ฅ์„ ์ œ๊ณตํ•ฉ๋‹ˆ๋‹ค. ์—ฐ๊ตฌ ์š”์•ฝ ์‹ ํฅ ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ์žฅ๋‚ด ๋ฏธ์ƒ๋ฌผ๊ตฐ, ํŠนํžˆ ๊ทธ ๊ณฐํŒก์ด ์„ฑ๋ถ„์ด ์‹ ๊ฒฝํ‡ดํ–‰์„ฑ ์งˆํ™˜์—์„œ ์ค‘์š”ํ•œ ์—ญํ• ์„ ํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์žฅ๋‚ด ๊ณฐํŒก์ด๋Š” ์‹ ๊ฒฝ ์—ผ์ฆ ๋ฐ ์‹ ๊ฒฝ ์„ธํฌ ๊ฑด๊ฐ•์— ์˜ํ–ฅ์„ ๋ฏธ์น˜๋Š” ๋Œ€์‚ฌ ์‚ฐ๋ฌผ์„ ์ƒ์„ฑํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ์ƒํ˜ธ์ž‘์šฉ์„ ์ดํ•ดํ•˜๋Š” ๊ฒƒ์€ ์‹ ๊ฒฝํ‡ดํ–‰์„ฑ ์งˆํ™˜์˜ ์˜ํ–ฅ์„ ์™„ํ™”ํ•˜๊ธฐ ์œ„ํ•œ ์ƒˆ๋กœ์šด ์น˜๋ฃŒ ์ „๋žต ๊ฐœ๋ฐœ์— ํ•„์ˆ˜์ ์ž…๋‹ˆ๋‹ค. ์˜ˆ๋ฅผ ๋“ค์–ด, Nature Reviews Neuroscience์— ๋ฐœํ‘œ๋œ ์—ฐ๊ตฌ๋Š” ๊ณฐํŒก์ด๋ฅผ ํฌํ•จํ•œ ์žฅ๋‚ด ๋ฏธ์ƒ๋ฌผ๊ตฐ์ด ์•Œ์ธ ํ•˜์ด๋จธ๋ณ‘๊ณผ ๊ฐ™์€ ์งˆํ™˜์—์„œ ์ค‘์š”ํ•œ ์‹ ๊ฒฝ ์—ผ์ฆ ๋ฐ˜์‘์„ ์กฐ์ ˆํ•˜๋Š” ์ž ์žฌ๋ ฅ์„ ๊ฐ•์กฐํ•ฉ๋‹ˆ๋‹ค (Zhang et al., 2021). ๊ด€๋ จ ์ƒ๋ฌผํ•™์  ๋ฉ”์ปค๋‹ˆ์ฆ˜ ์žฅ-๋‡Œ ์ถ•์€ ์œ„์žฅ๊ด€๊ณผ ์ค‘์ถ” ์‹ ๊ฒฝ๊ณ„ ๊ฐ„์˜ ๋ณต์žกํ•œ ํ†ต์‹  ๋„คํŠธ์›Œํฌ์ž…๋‹ˆ๋‹ค. ๊ณฐํŒก์ด ์„ฑ๋ถ„์€ ๋ฉด์—ญ ๋ฐ˜์‘์„ ์กฐ์ ˆํ•˜๊ณ  …
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24th Jul 2025 Seรกn Mac Fhearraigh, PhD

Understanding the Role of APOE in Neurodegenerative Diseases

์‹ ๊ฒฝํ‡ดํ–‰์„ฑ ์งˆํ™˜์—์„œ APOE์˜ ์—ญํ•  ์ดํ•ดํ•˜๊ธฐ์ตœ๊ทผ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ์— ๋”ฐ๋ฅด๋ฉด ํŠน์ • ์œ ์ „์ž ๋ณ€์ด์ธ APOE๊ฐ€ ์•Œ์ธ ํ•˜์ด๋จธ๋ณ‘ ๋ฐ ํŒŒํ‚จ์Šจ๋ณ‘์˜ ์œ„ํ—˜์„ ํฌ๊ฒŒ ์ฆ๊ฐ€์‹œํ‚จ๋‹ค๊ณ  ํ•ฉ๋‹ˆ๋‹ค. ์ด๋Š” ๋‹ค์–‘ํ•œ ๋…ธํ™” ๊ด€๋ จ ๋‡Œ ์งˆํ™˜์—์„œ์˜ ์—ญํ• ์„ ๊ฐ•์กฐํ•˜๋ฉฐ, ์ด ๋ฐœ๊ฒฌ์€ ์—ฐ๊ตฌ์™€ ์ž ์žฌ์ ์ธ ์น˜๋ฃŒ ๊ฐœ์ž…์„ ์œ„ํ•œ ์ƒˆ๋กœ์šด ๊ธธ์„ ์—ด์–ด์ค๋‹ˆ๋‹ค.์—ฐ๊ตฌ ์š”์•ฝAPOE ์œ ์ „์ž๋Š” ํŠนํžˆ ๊ทธ ฮต4 ๋ณ€์ด๊ฐ€ ์•Œ์ธ ํ•˜์ด๋จธ๋ณ‘์˜ ์ฃผ์š” ์œ ์ „์  ์œ„ํ—˜ ์ธ์ž๋กœ ํ™•์ธ๋˜์—ˆ์Šต๋‹ˆ๋‹ค. ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด ์ด ๋ณ€์ด๋ฅผ ๊ฐ€์ง„ ๊ฐœ์ธ์€ ์•Œ์ธ ํ•˜์ด๋จธ๋ณ‘๋ฟ๋งŒ ์•„๋‹ˆ๋ผ ํŒŒํ‚จ์Šจ๋ณ‘ ๋ฐ ๋‹ค์–‘ํ•œ ๋…ธํ™” ๊ด€๋ จ ๋‡Œ ์งˆํ™˜์— ๋Œ€ํ•ด์„œ๋„ ๋†’์€ ์œ„ํ—˜์— ์ฒ˜ํ•ด ์žˆ์Šต๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ๋ฐœ๊ฒฌ์˜ ์˜๋ฏธ๋Š” ๊นŠ์œผ๋ฉฐ, ์ด๋“ค ์งˆํ™˜ ๊ฐ„์˜ ๊ณต์œ ๋œ ์ƒ๋ฌผํ•™์  ๊ฒฝ๋กœ๋ฅผ ์ œ์•ˆํ•˜์—ฌ ๋ณด๋‹ค ํšจ๊ณผ์ ์ธ ์น˜๋ฃŒ ์ „๋žต์œผ๋กœ ์ด์–ด์งˆ ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. Nature Reviews Neuroscience์— ๋ฐœํ‘œ๋œ ๋ฉ”ํƒ€ ๋ถ„์„์€ ฮต4 ๋Œ€๋ฆฝ์œ ์ „์ž๊ฐ€ ์•Œ์ธ ํ•˜์ด๋จธ๋ณ‘๊ณผ ํŒŒํ‚จ์Šจ๋ณ‘ ๋ชจ๋‘์˜ ์œ„ํ—˜ ์ฆ๊ฐ€์™€ ๊ด€๋ จ์ด ์žˆ์Œ์„ ๋‚˜ํƒ€๋ƒ…๋‹ˆ๋‹ค.๊ด€๋ จ ์ƒ๋ฌผํ•™์  ๋ฉ”์ปค๋‹ˆ์ฆ˜APOE ๋‹จ๋ฐฑ์งˆ์€ ์ง€์งˆ ๋Œ€์‚ฌ ๋ฐ ์‹ ๊ฒฝ ์„ธํฌ ๋ณต๊ตฌ์—์„œ ์ค‘์š”ํ•œ ์—ญํ• ์„ ํ•ฉ๋‹ˆ๋‹ค. ๊ทธ ฮต4 ๋ณ€์ด๋Š” ์•Œ์ธ ํ•˜์ด๋จธ๋ณ‘ ๋ณ‘๋ฆฌ์˜ ์ฃผ์š” ํŠน์ง•์ธ ์•„๋ฐ€๋กœ์ด๋“œ ๋ฒ ํƒ€์˜ ์ œ๊ฑฐ๋ฅผ ๋ฐฉํ•ดํ•˜๋Š” ๊ฒƒ๊ณผ ๊ด€๋ จ์ด ์žˆ์Šต๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ๋ฐฉํ•ด๋Š” ์‹ ๊ฒฝ ์—ผ์ฆ ๋ฐ ์‹ ๊ฒฝ ์„ธํฌ ์‚ฌ๋ฉธ๋กœ ์ด์–ด์ ธ ์‹ ๊ฒฝํ‡ดํ–‰์„ฑ ์งˆํ™˜์˜ ์ง„ํ–‰์— ๊ธฐ์—ฌํ•  ์ˆ˜ ์žˆ์Šต๋‹ˆ๋‹ค. ์ด๋Ÿฌํ•œ ๋ฉ”์ปค๋‹ˆ์ฆ˜์„ ์ดํ•ดํ•˜๋Š” ๊ฒƒ์€ APOE ๊ด€๋ จ ์œ„ํ—˜์˜ ์˜ํ–ฅ์„ ์™„ํ™”ํ•  ์ˆ˜ ์žˆ๋Š” ํ‘œ์  ์น˜๋ฃŒ๋ฒ• ๊ฐœ๋ฐœ์— ํ•„์ˆ˜์ ์ž…๋‹ˆ๋‹ค. ์—ฐ๊ตฌ์— ๋”ฐ๋ฅด๋ฉด APOE ฮต4 …
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24th Jul 2025 Seรกn Mac Fhearraigh, PhD
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