BDNF / TrkB Neurotrophin Antibody Sampler Pack

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SKU:
ABSP039
Product Type:
Antibody
Size:
Antibody Sampler Pack
Size:
8 X 20μL
Reactivity:
Human
Mouse
Rat
Analytes:
BDNF
TrkB/NTRK2
Phospho-TrkB
NGF
TrkA/NTRK1
p75/NGFR
CREB
Phospho-CREB
  • Anti-BDNF [ARC0303] Monoclonal Antibody (CAB4873)
  • Anti-TrkB [ARC53486] Monoclonal Antibody (CAB21232)
  • Anti-Phospho-TrkA-Y674/675 + TrkB-Y706/707 Antibody (CABP0549)
  • Anti-NGF Antibody (CAB13922)
  • Anti-TrkA+B+C [ARC2649] Monoclonal Antibody (CAB2693)
  • Anti-NGFR Antibody (CAB11169)
  • Anti-CREB1 Antibody (CAB11989)
  • Anti-Phospho-CREB1-S133 [ARC60280] Monoclonal Antibody (CABP1421)

Description

BDNF / TrkB Neurotrophin Antibody Sampler Pack

The BDNF / TrkB Neurotrophin Antibody Sampler Pack from Assay Genie brings together 8 rigorously validated antibodies spanning the key nodes of this pathway, supplied in a convenient 20µL trial size. It lets researchers screen an entire signalling axis in a single, cost-effective pack — validated for applications including ELISA, IF/ICC, IHC-P, IP, WB — before committing to full-size vials. Each antibody is also available individually in a full 100µL size.

TargetAntibodyCat. No.HostReactivityApplicationsSize
BDNFAnti-BDNF [ARC0303] Monoclonal AntibodyCAB4873-20RabbitHuman, Mouse, RatIF/ICCELISA20µL
TrkB/NTRK2Anti-TrkB [ARC53486] Monoclonal AntibodyCAB21232-20RabbitMouse, RatWBELISA20µL
Phospho-TrkBAnti-Phospho-TrkA-Y674/675 + TrkB-Y706/707 AntibodyCABP0549-20RabbitHumanWBELISA20µL
NGFAnti-NGF AntibodyCAB13922-20RabbitHuman, MouseWBELISA20µL
TrkA/NTRK1Anti-TrkA+B+C [ARC2649] Monoclonal AntibodyCAB2693-20RabbitHuman, Mouse, RatWBIHC-PELISA20µL
p75/NGFRAnti-NGFR AntibodyCAB11169-20RabbitHuman, Mouse, RatWBIF/ICCELISA20µL
CREBAnti-CREB1 AntibodyCAB11989-20RabbitHuman, Mouse, RatWBIHC-PIF/ICCIPELISA20µL
Phospho-CREBAnti-Phospho-CREB1-S133 [ARC60280] Monoclonal AntibodyCABP1421-20RabbitHuman, Mouse, RatIHC-PELISA20µL

Neurotrophins are secreted growth factors that govern neuronal survival, differentiation, synaptic plasticity, and the formation and maintenance of circuits throughout life. They signal through two receptor classes: the high-affinity Trk receptor tyrosine kinases, which mediate trophic and survival responses, and the pan-neurotrophin receptor p75, which can promote either survival or apoptosis depending on context. The most abundant neurotrophin in the adult brain is BDNF, which is essential for activity-dependent synaptic plasticity, long-term potentiation, and learning and memory. BDNF binds its cognate receptor TrkB/NTRK2, triggering receptor dimerization and autophosphorylation; the activated, phosphorylated receptor, detected as Phospho-TrkB, recruits adaptor proteins that engage the Ras-ERK, PI3K-Akt, and PLC-gamma cascades to support neuronal survival and synaptic strengthening. A parallel axis is defined by NGF, the prototypical neurotrophin that supports sensory and sympathetic neurons and cholinergic populations, acting through its receptor TrkA/NTRK1. The shared receptor p75/NGFR modulates ligand affinity and specificity for the Trk receptors and can independently initiate pro-apoptotic signaling, particularly in response to pro-neurotrophins. A central downstream node of neurotrophin signaling is the transcription factor CREB, which upon phosphorylation to Phospho-CREB drives expression of plasticity- and survival-related genes, including BDNF itself, establishing a feed-forward loop that reinforces synaptic and circuit changes. Disruption of this signaling network is implicated in depression, neurodegeneration, and impaired neural repair, and it is a major target for therapeutic intervention. Together these molecules trace the path from neurotrophin ligand to receptor activation to transcriptional output. This pack brings together validated antibodies against BDNF, TrkB/NTRK2, Phospho-TrkB, NGF, TrkA/NTRK1, p75/NGFR, CREB, and Phospho-CREB to support analysis of neurotrophin signaling.

AnalyteAlternate Names
BDNFBrain-derived neurotrophic factor
TrkB/NTRK2NTRK2, TrkB, Tropomyosin receptor kinase B, GP145-TrkB
Phospho-TrkBNTRK2, TrkB (phosphorylated)
NGFNerve growth factor, Beta-NGF, NGFB
TrkA/NTRK1NTRK1, TrkA, Tropomyosin receptor kinase A, MTC, TRK
p75/NGFRNGFR, p75, p75NTR, Nerve growth factor receptor, CD271, TNFRSF16
CREBCREB1, cAMP response element-binding protein 1
Phospho-CREBCREB1, cAMP response element-binding protein (phospho-Ser133)
SpecificationDetail
Pack Format8 antibodies, 20µL each (trial size)
StorageStore at -20°C upon receipt
Shelf Life12 months from date of receipt
ShippingGel pack
Scale-upEvery antibody is also available individually in a full 100µL size

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