Axon Guidance & Cytoskeleton Antibody Sampler Pack

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SKU:
ABSP037
Product Type:
Antibody
Size:
Antibody Sampler Pack
Size:
8 X 20μL
Reactivity:
Human
Mouse
Rat
Analytes:
Neurofilament (NF-L)
Tau
GAP-43
Doublecortin/DCX
Neuropilin-1 / NRP1
Robo1
Semaphorin 3A
EphA4
  • Anti-Neurofilament L [ARC50056] Monoclonal Antibody (CAB20269)
  • Anti-Tau Antibody (CAB0002)
  • Anti-GAP43 [ARC0246] Monoclonal Antibody (CAB19055)
  • Anti-Doublecortin [ARC57902] Monoclonal Antibody (CAB23501)
  • Anti-Neuropilin-1 (NRP1) Monoclonal Antibody (CAB19087)
  • Anti-ROBO1 Antibody (CAB15313)
  • Anti-Semaphorin 3A [ARC56474] Monoclonal Antibody (CAB22204)
  • Anti-EPHA4 Antibody (CAB8346)

Description

Axon Guidance & Cytoskeleton Antibody Sampler Pack

The Axon Guidance & Cytoskeleton Antibody Sampler Pack from Assay Genie brings together 8 rigorously validated antibodies spanning the key nodes of this pathway, supplied in a convenient 20µL trial size. It lets researchers screen an entire signalling axis in a single, cost-effective pack — validated for applications including ELISA, IF/ICC, IHC-P, WB — before committing to full-size vials. Each antibody is also available individually in a full 100µL size.

TargetAntibodyCat. No.HostReactivityApplicationsSize
Neurofilament (NF-L)Anti-Neurofilament L [ARC50056] Monoclonal AntibodyCAB20269-20RabbitHuman, Mouse, RatWBIHC-PIF/ICCELISA20µL
TauAnti-Tau AntibodyCAB0002-20RabbitHuman, Mouse, RatWBIHC-PIF/ICCELISA20µL
GAP-43Anti-GAP43 [ARC0246] Monoclonal AntibodyCAB19055-20RabbitHuman, Mouse, RatWBIF/ICCELISA20µL
Doublecortin/DCXAnti-Doublecortin [ARC57902] Monoclonal AntibodyCAB23501-20RabbitHuman, Mouse, RatWBELISA20µL
Neuropilin-1 / NRP1Anti-Neuropilin-1 (NRP1) Monoclonal AntibodyCAB19087-20RabbitHuman, Mouse, RatWBELISA20µL
Robo1Anti-ROBO1 AntibodyCAB15313-20RabbitHuman, Mouse, RatWBIF/ICCELISA20µL
Semaphorin 3AAnti-Semaphorin 3A [ARC56474] Monoclonal AntibodyCAB22204-20RabbitHuman, MouseWBELISA20µL
EphA4Anti-EPHA4 AntibodyCAB8346-20RabbitHuman, Mouse, RatWBIF/ICCELISA20µL

The construction of neural circuits depends on the precise navigation of growing axons and the dynamic remodeling of the neuronal cytoskeleton. Growth cones at the tips of extending axons integrate attractive and repulsive cues to steer toward their targets, and this guidance machinery is also reactivated during regeneration and plasticity. Several classic guidance systems are represented here. Semaphorin 3A is a secreted repulsive cue that collapses growth cones, and it signals through a receptor complex in which Neuropilin-1 / NRP1 serves as the principal ligand-binding subunit. Slit-Robo signaling provides midline repulsion, with Robo1 acting as the receptor that prevents inappropriate crossing of axons. The Eph-ephrin system contributes contact-mediated repulsion and topographic mapping, exemplified by the receptor EphA4, which regulates axon pathfinding and synaptic organization. The structural and motile properties of axons rely on a coordinated cytoskeleton. Neurofilament (NF-L), the light subunit of neuronal intermediate filaments, provides axonal caliber and structural stability and is a sensitive marker of axonal injury and degeneration. Tau stabilizes axonal microtubules and regulates their assembly and transport. Two markers track growth and structural plasticity directly: GAP-43 is a growth-associated phosphoprotein enriched in growth cones and regenerating axons that reflects active outgrowth, while Doublecortin/DCX is a microtubule-binding protein expressed in migrating neuroblasts and immature neurons, serving as a definitive marker of neurogenesis and neuronal migration. Together these targets connect the extracellular guidance cues that direct wiring to the intracellular cytoskeletal proteins that execute movement and maintain axonal integrity, processes whose disruption underlies developmental malformations, axonopathies, and failed regeneration after injury. This pack brings together validated antibodies against Neurofilament (NF-L), Tau, GAP-43, Doublecortin/DCX, Neuropilin-1 / NRP1, Robo1, Semaphorin 3A, and EphA4 to support study of axon guidance and the neuronal cytoskeleton.

AnalyteAlternate Names
Neurofilament (NF-L)NEFL, Neurofilament light polypeptide, NF-L, NFL
TauMAPT, Microtubule-associated protein tau, PHF-tau, MAPTL, MTBT1
GAP-43GAP43, Neuromodulin, B-50, Neural phosphoprotein B-50
Doublecortin/DCXDCX, Doublecortin, Lissencephalin-X, LIS-X
Neuropilin-1 / NRP1NRP1, Neuropilin-1, CD304, VEGF165R, BDCA4
Robo1Roundabout guidance receptor 1, DUTT1, SAX3
Semaphorin 3ASEMA3A, Semaphorin-3A, SEMAD, SEMAIII, Collapsin-1
EphA4EPHA4, Ephrin type-A receptor 4, SEK, TYRO1
SpecificationDetail
Pack Format8 antibodies, 20µL each (trial size)
StorageStore at -20°C upon receipt
Shelf Life12 months from date of receipt
ShippingGel pack
Scale-upEvery antibody is also available individually in a full 100µL size

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