Anti-RGAP1 Antibody (CAB19236)
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주문- SKU:
- CAB19236
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- RACGAP1
- Synonyms:
- CYK4
- Synonyms:
- HsCYK-4
- Synonyms:
- ID-GAP
- Synonyms:
- MgcRacGAP
- Synonyms:
- rac GTPase-activating protein 1
Description
| Product Name: | RGAP1 Rabbit mAb |
| Product Code: | CAB19236 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | RACGAP1, CYK4, HsCYK-4, ID-GAP, MgcRacGAP, rac GTPase-activating protein 1 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human RGAP1. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, NIH/3T3, K-562, PC-12 |
| Immunogen: | Recombinant protein of human RGAP1. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 29127 |
| Uniprot: | Q9H0H5 |
| Cellular Location: | Cell membrane, Cleavage furrow, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Midbody, Nucleus, Peripheral membrane protein, acrosome, cytoskeleton, secretory vesicle, spindle |
| Calculated MW: | 71kDa |
| Observed MW: | 70KDa |
| UniProt Protein Function: | MgcRacGAP: a rac GTPase activating protein. Plays an important role in cytokinesis by regulating cortical movement through RhoA. Phosphorylation by Aurora B apparently induces GAP activity toward RhoA. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Rac/Rho Chromosomal Location of Human Ortholog: 12q13.12 Cellular Component: nucleoplasm; microtubule; extrinsic to internal side of plasma membrane; acrosome; spindle midzone; midbody; nucleus; cytosol; cleavage furrow Molecular Function:gamma-tubulin binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; metal ion binding; microtubule binding; beta-tubulin binding; protein kinase binding; GTPase activator activity; alpha-tubulin binding Biological Process: positive regulation of cytokinesis; regulation of attachment of spindle microtubules to kinetochore; spindle midzone assembly involved in mitosis; antigen processing and presentation of exogenous peptide antigen via MHC class II; sulfate transport; microtubule-based movement; regulation of small GTPase mediated signal transduction; embryonic development; cytokinesis after mitosis; small GTPase mediated signal transduction; neuroblast proliferation; spermatogenesis; blood coagulation; cytokinesis, contractile ring formation; positive regulation of GTPase activity |
| NCBI Summary: | The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q9H0H5 |
| NCBI GenInfo Identifier: | 74762727 |
| NCBI Gene ID: | 29127 |
| NCBI Accession: | Q9H0H5.1 |
| UniProt Secondary Accession: | Q9H0H5,Q6PJ26, Q9NWN2, Q9P250, Q9P2W2, |
| UniProt Related Accession: | Q9H0H5 |
| Molecular Weight: | 632 |
| NCBI Full Name: | Rac GTPase-activating protein 1 |
| NCBI Synonym Full Names: | Rac GTPase activating protein 1 |
| NCBI Official Symbol: | RACGAP1 |
| NCBI Official Synonym Symbols: | CYK4; ID-GAP; HsCYK-4; MgcRacGAP |
| NCBI Protein Information: | rac GTPase-activating protein 1; RACGAP1; protein CYK4 homolg; protein CYK4 homolog; male germ cell RacGap; GTPase activating protein |
| UniProt Protein Name: | Rac GTPase-activating protein 1 |
| UniProt Synonym Protein Names: | Male germ cell RacGap; MgcRacGAP; Protein CYK4 homolog; CYK4; HsCYK-4 |
| Protein Family: | Rac GTPase-activating protein |
| UniProt Gene Name: | RACGAP1 |
| UniProt Entry Name: | RGAP1_HUMAN |
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