Anti-RCHY1 Antibody (CAB19287)

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SKU:
CAB19287
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
RCHY1
Synonyms:
ARNIP
Synonyms:
CHIMP
Synonyms:
PIRH2
Synonyms:
PRO1996
Synonyms:
RNF199
Synonyms:
ZCHY
Synonyms:
ZNF363
Synonyms:
ring finger and CHY zinc finger domain containing 1
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Description

Product Name:RCHY1 Rabbit mAb
Product Code:CAB19287
Size:20uL, 50uL, 100uL
Synonyms:RCHY1, ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363, ring finger and CHY zinc finger domain containing 1
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human RCHY1.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Immunogen:Recombinant protein of human RCHY1.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:25898
Uniprot:Q96PM5
Cellular Location:Cytoplasm, Nucleus, Nucleus speckle
Calculated MW:30kDa
Observed MW:Refer to figures
UniProt Protein Function:RCHY1: Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, HDAC1 and p27Kip1. Preferentially acts on tetrameric p53/TP53. Contributes to the regulation of p27Kip1 and p53/TP53 levels, and thereby contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity. Monomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, p27Kip1, COPE, UBE2D2 and GORAB/NTKLBP1. Up-regulated during the S phase of the cell cycle. Expressed at low levels during G phase. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin ligase; Ubiquitin conjugating system; Nuclear receptor co-regulator; EC 6.3.2.-; EC 6.3.2.19

Chromosomal Location of Human Ortholog: 4q21.1

Cellular Component: nucleoplasm; cytoplasm; nuclear speck; nucleus; ubiquitin ligase complex

Molecular Function:protein binding; protein homodimerization activity; zinc ion binding; p53 binding; ubiquitin-protein ligase activity; ligase activity; receptor binding

Biological Process: protein autoubiquitination; positive regulation of protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination

NCBI Summary:The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]
UniProt Code:Q96PM5
NCBI GenInfo Identifier:32700008
NCBI Gene ID:25898
NCBI Accession:Q96PM5.1
UniProt Related Accession:Q96PM5
Molecular Weight:30 kDa
NCBI Full Name:RING finger and CHY zinc finger domain-containing protein 1
NCBI Synonym Full Names:ring finger and CHY zinc finger domain containing 1
NCBI Official Symbol:RCHY1  
NCBI Official Synonym Symbols:ZCHY; ARNIP; CHIMP; PIRH2; RNF199; ZNF363; PRO1996  
NCBI Protein Information:RING finger and CHY zinc finger domain-containing protein 1
UniProt Protein Name:RING finger and CHY zinc finger domain-containing protein 1
UniProt Synonym Protein Names:Androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; RING finger protein 199; Zinc finger protein 363; p53-induced RING-H2 protein; hPirh2
Protein Family:RING finger and CHY zinc finger domain-containing protein
UniProt Gene Name:RCHY1  
UniProt Entry Name:ZN363_HUMAN
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