Anti-QK1 Antibody (CAB0193)
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주문- SKU:
- CAB0193
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- QKI
- Synonyms:
- Hqk
- Synonyms:
- QK
- Synonyms:
- QK1
- Synonyms:
- QK3
- Synonyms:
- hqkI
- Synonyms:
- protein quaking
Frequently bought together:
Description
| Product Name: | QK1 Rabbit mAb |
| Product Code: | CAB0193 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | QKI, Hqk, QK, QK1, QK3, hqkI, protein quaking |
| Applications: | WB, IF, IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human QK1. |
| Applications: | WB, IF, IP |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SKOV3, NIH/3T3, U-251MG, Neuro-2a, Mouse brain, Rat brain, Rat heart |
| Immunogen: | A synthesized peptide derived from human QK1. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9444 |
| Uniprot: | Q96PU8 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 38kDa |
| Observed MW: | 38KDa/40KDa |
| UniProt Protein Function: | RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor. |
| NCBI Summary: | The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q96PU8 |
| NCBI GenInfo Identifier: | 74761039 |
| NCBI Gene ID: | 9444 |
| NCBI Accession: | Q96PU8.1 |
| UniProt Secondary Accession: | Q96PU8,Q2I375, Q5MJQ1, Q969L9, Q96EJ3, Q96KA3, Q96PU6 Q96PU7, Q9P0X6, Q9P0X7, Q9P0X8, Q9P0X9, |
| UniProt Related Accession: | Q96PU8 |
| Molecular Weight: | 35,131 Da |
| NCBI Full Name: | Protein quaking |
| NCBI Synonym Full Names: | QKI, KH domain containing RNA binding |
| NCBI Official Symbol: | QKI |
| NCBI Official Synonym Symbols: | QK; Hqk; QK1; QK3; hqkI |
| NCBI Protein Information: | protein quaking |
| UniProt Protein Name: | Protein quaking |
| Protein Family: | Protein quaking |
| UniProt Gene Name: | QKI |
| UniProt Entry Name: | QKI_HUMAN |
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