Anti-Phospho-MLKL-S454 Antibody (CABP1173)

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SKU:
CABP1173
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MLKL
Synonyms:
hMLKL
Synonyms:
mixed lineage kinase domain-like protein
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Description

Product Name:Phospho-MLKL-S454 Rabbit pAb
Product Code:CABP1173
Size:20uL, 50uL, 100uL
Synonyms:MLKL, hMLKL, mixed lineage kinase domain-like protein
Applications:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A phospho synthetic peptide corresponding to residues surrounding S454 of human MLKL.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:HeLa
Immunogen:A phospho synthetic peptide corresponding to residues surrounding S454 of human MLKL.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:197259
Uniprot:Q8NB16
Cellular Location:Cell membrane, Cytoplasm
Calculated MW:53kDa/54kDa
Observed MW:54kDa
UniProt Protein Function:MLKL: Belongs to the protein kinase superfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; TKL-Unique family

Chromosomal Location of Human Ortholog: 16q23.1

Cellular Component: cytoplasm; cytosol; plasma membrane

Molecular Function:ATP binding; protein binding; protein complex binding; protein kinase activity; signal transducer activity

Biological Process: protein amino acid phosphorylation

NCBI Summary:This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
UniProt Code:Q8NB16
NCBI GenInfo Identifier:74762545
NCBI Gene ID:197259
NCBI Accession:Q8NB16.1
UniProt Secondary Accession:Q8NB16,Q8N6V0, A6NCE4,
UniProt Related Accession:Q8NB16
Molecular Weight:54kDa
NCBI Full Name:Mixed lineage kinase domain-like protein
NCBI Synonym Full Names:mixed lineage kinase domain like pseudokinase
NCBI Official Symbol:MLKL  
NCBI Official Synonym Symbols:hMLKL  
NCBI Protein Information:mixed lineage kinase domain-like protein
UniProt Protein Name:Mixed lineage kinase domain-like protein
UniProt Gene Name:MLKL  
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