Anti-p70 S6 Kinase 2 Antibody (CAB9100)

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주문
SKU:
CAB9100
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
KLS
Synonyms:
P70-beta
Synonyms:
P70-beta-1
Synonyms:
P70-beta-2
Synonyms:
S6K-beta2
Synonyms:
S6K2
Synonyms:
SRK
Synonyms:
STK14B
Synonyms:
p70(S6K)-beta
Synonyms:
p70S6Kb
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Description

Product Name:p70 S6 Kinase 2 Rabbit mAb
Product Code:CAB9100
Size:20uL, 50uL, 100uL
Synonyms:KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B, p70(S6K)-beta, p70S6Kb
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human p70 S6 Kinase 2
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain
Immunogen:A synthesized peptide derived from human p70 S6 Kinase 2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6199
Uniprot:Q9UBS0
Cellular Location:Cytoplasm, Nucleus
Calculated MW:53kDa
Observed MW:60kDa
UniProt Protein Function:P70S6KB: an AGC kinase of the RSK family that is required for cell growth and G1 cell cycle progression. Is phosphorylated and activated by mTOR in mitogenic pathways downstream of phosphoinositide 3 kinase (PI3K). Phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. Activity is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains. Mouse knockout shows symptoms of insulin resistance, and increased insulin senstivity, resulting in protection against diet-induced obesity. Protein expression and activation upregulated in colon adenocarcinoma cell lines. Increased expression in breast cancer correlated with poor survival. Selectively amplified and overexpressed within the 17q23 breast cancer amplicon. Two isoforms produced by alternative initiation have been reported.
UniProt Protein Details:

Protein type:EC 2.7.11.1; Protein kinase, AGC; Translation; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; AGC group; RSK family; p70 subfamily

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: cytoplasm; nucleoplasm

Molecular Function:ATP binding; peptide binding; protein kinase activity; protein serine/threonine kinase activity; ribosomal protein S6 kinase activity

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; nerve growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of translational initiation; protein amino acid phosphorylation; protein kinase B signaling cascade; signal transduction; translation

NCBI Summary:This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]
UniProt Code:Q9UBS0
NCBI GenInfo Identifier:296434560
NCBI Gene ID:6199
NCBI Accession:Q9UBS0.2
UniProt Secondary Accession:Q9UBS0,O94809, Q9UEC1, B2RMZ9, B4DML8,
UniProt Related Accession:Q9UBS0
Molecular Weight:16,868 Da
NCBI Full Name:Ribosomal protein S6 kinase beta-2
NCBI Synonym Full Names:ribosomal protein S6 kinase B2
NCBI Official Symbol:RPS6KB2  
NCBI Official Synonym Symbols:KLS; SRK; S6K2; STK14B; p70S6Kb; P70-beta; S6K-beta2; P70-beta-1; P70-beta-2; p70(S6K)-beta  
NCBI Protein Information:ribosomal protein S6 kinase beta-2
UniProt Protein Name:Ribosomal protein S6 kinase beta-2
UniProt Synonym Protein Names:70 kDa ribosomal protein S6 kinase 2; P70S6K2; p70-S6K 2; S6 kinase-related kinase; SRK; Serine/threonine-protein kinase 14B; p70 ribosomal S6 kinase beta; S6K-beta; p70 S6 kinase beta; p70 S6K-beta; p70 S6KB; p70-beta
Protein Family:Ribosomal protein S6 kinase
UniProt Gene Name:RPS6KB2  
UniProt Entry Name:KS6B2_HUMAN
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