Anti-Neurofilament L Antibody (CAB20269)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- CAB20269
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- NEFL
- Synonyms:
- CMT1F
- Synonyms:
- CMT2E
- Synonyms:
- NF-L
- Synonyms:
- NF68
- Synonyms:
- NFL
- Synonyms:
- PPP1R110
Description
| Product Name: | Neurofilament L Rabbit mAb |
| Product Code: | CAB20269 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | NEFL, CMT1F, CMT2E, NF-L, NF68, NFL, PPP1R110 |
| Applications: | WB, IHC, IF, IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human Neurofilament L. |
| Applications: | WB, IHC, IF, IP |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, Mouse brain, Rat brain |
| Immunogen: | Recombinant protein of human Neurofilament L. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4747 |
| Uniprot: | P07196 |
| Observed MW: | 70KDa |
| UniProt Protein Function: | NFL: one of the three (L, M, and H) intermediate filament proteins that form neurofilaments. Neurofilaments are involved in the maintenance of neuronal caliber. NF-L is the most abundant of the three neurofilament proteins. Defects cause Charcot-Marie-Tooth disease type 1F (CMT1F). |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 8p21 Cellular Component: TSC1-TSC2 complex; growth cone; axon; cytoplasm; neurofilament; cytosol Molecular Function:protein C-terminus binding; protein binding, bridging; identical protein binding; protein domain specific binding; protein binding; phospholipase binding; structural constituent of cytoskeleton Biological Process: protein polymerization; response to peptide hormone stimulus; neurofilament bundle assembly; response to toxin; intermediate filament organization; microtubule cytoskeleton organization and biogenesis; retrograde axon cargo transport; axon regeneration in the peripheral nervous system; synaptic transmission; axon transport of mitochondrion; regulation of axon diameter; positive regulation of axonogenesis; negative regulation of neuron apoptosis; anterograde axon cargo transport; neuromuscular process controlling balance; locomotion; neurite morphogenesis; response to corticosterone stimulus Disease: Charcot-marie-tooth Disease, Axonal, Type 2e; Charcot-marie-tooth Disease, Demyelinating, Type 1f |
| NCBI Summary: | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P07196 |
| NCBI GenInfo Identifier: | 62511894 |
| NCBI Gene ID: | 4747 |
| NCBI Accession: | P07196.3 |
| UniProt Related Accession: | P07196 |
| Molecular Weight: | |
| NCBI Full Name: | Neurofilament light polypeptide |
| NCBI Synonym Full Names: | neurofilament light |
| NCBI Official Symbol: | NEFL |
| NCBI Official Synonym Symbols: | NFL; NF-L; NF68; CMT1F; CMT2E; CMTDIG; PPP1R110 |
| NCBI Protein Information: | neurofilament light polypeptide |
| UniProt Protein Name: | Neurofilament light polypeptide |
| UniProt Synonym Protein Names: | 68 kDa neurofilament protein; Neurofilament triplet L protein |
| Protein Family: | Neurofilament heavy polypeptide |
| UniProt Gene Name: | NEFL |
| UniProt Entry Name: | NFL_HUMAN |
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