The MUSK Antibody (CAB2591) is a high-quality antibody developed for reliable detection and analysis of target proteins. MuSK (Muscle-Specific Kinase) is a muscle-specific receptor tyrosine kinase that plays a key role in clustering acetylcholine receptors at the postsynaptic neuromuscular junction, regulating neuromuscular transmission. Mutations in this gene are associated with congenital myasthenic syndrome, and MuSK autoantibodies are found in a subset of myasthenia gravis patients.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse samples.
Product Name:
MUSK Antibody
SKU:
CAB2591
Size:
20μL, 100μL
Reactivity:
Mouse
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
CMS9, FADS, FADS1, MUSK
Positive Sample:
Mouse skeletal muscle
Cellular Localization:
Cell Junction, Single-Pass Type I Membrane Protein, Postsynaptic Cell Membrane, Synapse.
Calculated MW:
97kDa
Observed MW:
101kDa
This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.
Purification Method
Affinity purification
Gene ID
4593
RRID
AB_2764476
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from Mouse skeletal muscle, using MUSK Rabbit pAb (CAB2591) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s.
