Anti-Mouse CTLA-4 (CD152) In Vivo Antibody - Low Endotoxin

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SKU:
IVMB0049
Product Type:
In Vivo Monoclonal Antibody
Clone:
UC10-4F10-11
Protein:
CTLA-4
Isotype:
Armenian Hamster IgG1 kappa
Reactivity:
Mouse
Synonyms:
CD152
Synonyms:
Cytotoxic T Lymphocyte-Associated Antigen-4
Synonyms:
Ly-56
Research Area:
Immune Checkpoint & Cancer Biology
Endotoxin Level:
Low Endotoxin
Host Species:
Armenian Hamster
Applications:
FA
Applications:
FC
Applications:
IP
Applications:
WB
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Description

system_update_altTechnical Datasheet
Product Name:Anti-Mouse CTLA-4 (CD152) In Vivo Antibody - Low Endotoxin
Product Code:IVMB0049
Size:1mg, 5mg, 25mg, 50mg, 100mg
Clone:UC10-4F10-11
Protein:CTLA-4
Product Type:Monoclonal Antibody
Synonyms:CD152, Cytotoxic T Lymphocyte-Associated Antigen-4, Ly-56
Isotype:Armenian Hamster IgG1 κ
Reactivity:Mouse
Immunogen:Purified Recombinant Mouse CTLA4 Fc Fusion Protein
Applications:FA, FC, IP, WB
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Purity:≥95% monomer by analytical SEC
>95% by SDS Page
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Product CodeProduct NameEndotoxin Level
IVMB0049Anti-Mouse CTLA-4 (CD152) In Vivo Antibody - Low EndotoxinLow
IVMB0050Anti-Mouse CTLA-4 (CD152) In Vivo Antibody - Ultra Low EndotoxinUltra Low
Applications:FA, FC, IP, WB
Reactivity:Mouse
Host Species:Armenian Hamster
Specificity:Clone UC10-4F10-11 recognizes an epitope on mouse CTLA-4.
Antigen Distribution:CTLA-4 is expressed on activated T and B lymphocytes.
Immunogen:Purified Recombinant Mouse CTLA4 Fc Fusion Protein
Concentration:≥ 5.0 mg/ml
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Purity:≥95% monomer by analytical SEC
>95% by SDS Page
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity.

Technical Datasheet:View
Protein:CTLA-4
Function:Negative regulator of T cell activation
Ligand/Receptor:CD80 (B7-1), CD86 (B7-2)
Research Area:Immunology, Inhibitory Molecules
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