Anti-KAT8/MYST1/MOF Antibody (CAB3390)

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주문
SKU:
CAB3390
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MOF
Synonyms:
MYST1
Synonyms:
ZC2HC8
Synonyms:
hMOF
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Description

Product Name:KAT8/MYST1/MOF Rabbit mAb
Product Code:CAB3390
Size:20uL, 50uL, 100uL
Synonyms:MOF, MYST1, ZC2HC8, hMOF
Applications:WB, IHC, IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human KAT8/MYST1/MOF
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HepG2, MCF7, NIH/3T3
Immunogen:A synthesized peptide derived from human KAT8/MYST1/MOF
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:84148
Uniprot:Q9H7Z6
Cellular Location:Chromosome, Nucleus
Calculated MW:52kDa
Observed MW:53kDa
UniProt Protein Function:MYST1: Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Belongs to the MYST (SAS/MOZ) family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.3.1.48; Acetyltransferase

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: kinetochore; nucleoplasm; nuclear membrane; nucleus; histone acetyltransferase complex

Molecular Function:protein binding; histone acetyltransferase activity; enzyme binding; metal ion binding; acetyltransferase activity; histone acetyltransferase activity (H4-K16 specific); transcription factor binding; methylated histone residue binding

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; myeloid cell differentiation; regulation of autophagy; histone acetylation; negative regulation of transcription, DNA-dependent

NCBI Summary:This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Code:Q9H7Z6
NCBI GenInfo Identifier:68565938
NCBI Gene ID:84148
NCBI Accession:Q9H7Z6.2
UniProt Related Accession:Q9H7Z6
Molecular Weight:
NCBI Full Name:Histone acetyltransferase KAT8
NCBI Synonym Full Names:lysine acetyltransferase 8
NCBI Official Symbol:KAT8  
NCBI Official Synonym Symbols:MOF; hMOF; MYST1; ZC2HC8  
NCBI Protein Information:histone acetyltransferase KAT8
UniProt Protein Name:Histone acetyltransferase KAT8
UniProt Synonym Protein Names:Lysine acetyltransferase 8; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST-1; hMOF
Protein Family:Males-absent on the first protein
UniProt Gene Name:KAT8  
UniProt Entry Name:KAT8_HUMAN
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