Anti-iNOS Antibody (CAB3774)

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SKU:
CAB3774
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HEP-NOS
Synonyms:
INOS
Synonyms:
NOS
Synonyms:
NOS2A
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Description

Product Name:iNOS Rabbit mAb
Product Code:CAB3774
Size:20uL, 50uL, 100uL
Synonyms:HEP-NOS, INOS, NOS, NOS2A
Applications:WB, IF
Reactivity:Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human iNOS
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Mouse
Positive Samples:RAW264.7
Immunogen:A synthesized peptide derived from human iNOS
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4843
Uniprot:P35228
Calculated MW:131kDa
Observed MW:130KDa
UniProt Protein Function:Function: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
UniProt Protein Details:

Catalytic activity: 2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O.

Cofactor: Heme group

By similarity.Binds 1 FAD

By similarity.Binds 1 FMN

By similarity.Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme

By similarity.

Enzyme regulation: Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity

By similarity.

Subunit structure: Homodimer. Binds SLC9A3R1.

Tissue specificity: Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.

Induction: By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta. Ref.14

Polymorphism: Note=Genetic variations in NOS2 are involved in resistance to malaria [

MIM:611162].

Sequence similarities: Belongs to the NOS family.Contains 1 FAD-binding FR-type domain.Contains 1 flavodoxin-like domain.

NCBI Summary:Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
UniProt Code:P35228
NCBI GenInfo Identifier:1352513
NCBI Gene ID:4843
NCBI Accession:P35228.2
UniProt Secondary Accession:P35228,O60757, O94994, Q16263, Q16692, Q4TTS5, Q9UD42 A1L3U5, B7ZLY2,
UniProt Related Accession:P35228
Molecular Weight:131,117 Da
NCBI Full Name:Nitric oxide synthase, inducible
NCBI Synonym Full Names:nitric oxide synthase 2, inducible
NCBI Official Symbol:NOS2  
NCBI Official Synonym Symbols:NOS; INOS; NOS2A; HEP-NOS  
NCBI Protein Information:nitric oxide synthase, inducible; NOS type II; NOS, type II; inducible NOS; hepatocyte NOS; inducible NO synthase; nitric oxide synthase, macrophage; peptidyl-cysteine S-nitrosylase NOS2; nitric oxide synthase 2A (inducible, hepatocytes)
UniProt Protein Name:Nitric oxide synthase, inducible
UniProt Synonym Protein Names:Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2
Protein Family:Inositol 3-kinase
UniProt Gene Name:NOS2  
UniProt Entry Name:NOS2_HUMAN
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