Anti-HGD Antibody (CAB1400)

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주문
SKU:
CAB1400
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HGD
Synonyms:
AKU
Synonyms:
HGO
Synonyms:
homogentisate 1
Synonyms:
2-dioxygenase
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Description

Product Name:HGD Rabbit mAb
Product Code:CAB1400
Size:20uL, 50uL, 100uL
Synonyms:HGD, AKU, HGO, homogentisate 1, 2-dioxygenase
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human HGD.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HT-29, HepG2
Immunogen:A synthesized peptide derived from human HGD.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3081
Uniprot:Q93099
Calculated MW:48kDa
Observed MW:50KDa
UniProt Protein Function:HGD: Defects in HGD are the cause of alkaptonuria (AKU). AKU is an autosomal recessive error of metabolism characterized by an increase in the level of homogentisic acid. The clinical manifestations of AKU are urine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenous tissues, and spine arthritis. Belongs to the homogentisate dioxygenase family.
UniProt Protein Details:

Protein type:Oxidoreductase; EC 1.13.11.5; Amino Acid Metabolism - tyrosine

Chromosomal Location of Human Ortholog: 3q13.33

Cellular Component: cytosol

Molecular Function:homogentisate 1,2-dioxygenase activity; metal ion binding

Biological Process: L-phenylalanine catabolic process; tyrosine catabolic process

Disease: Alkaptonuria

NCBI Summary:This gene encodes the enzyme homogentisate 1,2 dioxygenase. This enzyme is involved in the catabolism of the amino acids tyrosine and phenylalanine. Mutations in this gene are the cause of the autosomal recessive metabolism disorder alkaptonuria.[provided by RefSeq, May 2010]
UniProt Code:Q93099
NCBI GenInfo Identifier:296434531
NCBI Gene ID:3081
NCBI Accession:Q93099.2
UniProt Secondary Accession:Q93099,A8K417, B2R8Z0,
UniProt Related Accession:Q93099
Molecular Weight:445
NCBI Full Name:Homogentisate 1,2-dioxygenase
NCBI Synonym Full Names:homogentisate 1,2-dioxygenase
NCBI Official Symbol:HGD  
NCBI Official Synonym Symbols:AKU; HGO  
NCBI Protein Information:homogentisate 1,2-dioxygenase; homogentisicase; homogentisate oxidase; homogentisate oxygenase; homogentisic acid oxidase
UniProt Protein Name:Homogentisate 1,2-dioxygenase
UniProt Synonym Protein Names:Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase
Protein Family:2-(hydroxymethyl)glutarate dehydrogenase
UniProt Gene Name:HGD  
UniProt Entry Name:HGD_HUMAN
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