Anti-DNA topoisomerase II alpha (TOP2A) Antibody (CAB0726)

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SKU:
CAB0726
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TOP2A
Synonyms:
TOP2
Synonyms:
TP2A
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Description

Product Name:DNA topoisomerase II alpha (TOP2A) Rabbit pAb
Product Code:CAB0726
Size:100uL
Synonyms:TOP2A, TOP2, TP2A
Applications:WB, IHC, IF
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide of human DNA topoisomerase II alpha (DNA topoisomerase II alpha (TOP2A))
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:20 - 1:50
Reactivity:Human
Positive Samples:HepG2
Immunogen:A synthetic peptide of human DNA topoisomerase II alpha (DNA topoisomerase II alpha (TOP2A))
Purification Method:Affinity purification
Storage:Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7153
Uniprot:P11388
Cellular Location:Cytoplasm, Nucleus, nucleoplasm
Calculated MW:174kDa/177kDa/178kDa/182kDa
Observed MW:190KDa
UniProt Protein Function:Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation.
NCBI Summary:This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
UniProt Code:P11388
NCBI GenInfo Identifier:13959709
NCBI Gene ID:7153
NCBI Accession:P11388.3
UniProt Secondary Accession:P11388,Q71UN1, Q71UQ5, Q9HB24, Q9HB25, Q9HB26, Q9UP44 Q9UQP9, B2RTS1,
UniProt Related Accession:P11388
Molecular Weight:182,681 Da
NCBI Full Name:DNA topoisomerase 2-alpha
NCBI Synonym Full Names:topoisomerase (DNA) II alpha
NCBI Official Symbol:TOP2A  
NCBI Official Synonym Symbols:TOP2; TP2A  
NCBI Protein Information:DNA topoisomerase 2-alpha
UniProt Protein Name:DNA topoisomerase 2-alpha
UniProt Synonym Protein Names:DNA topoisomerase II, alpha isozyme
Protein Family:DNA topoisomerase
UniProt Gene Name:TOP2A  
UniProt Entry Name:TOP2A_HUMAN
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