| UniProt Protein Function: | Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. |
| NCBI Summary: | This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NPF5 |
| NCBI GenInfo Identifier: | 78000211 |
| NCBI Gene ID: | 55929 |
| NCBI Accession: | NP_001029195.1 |
| UniProt Secondary Accession: | Q9NPF5,Q0JSM4, Q5TG41, Q7Z3H7, Q9H0S8, Q9P2C2, A8K001 D3DPY8, |
| UniProt Related Accession: | Q9NPF5 |
| Molecular Weight: | 52,993 Da |
| NCBI Full Name: | DNA methyltransferase 1-associated protein 1 |
| NCBI Synonym Full Names: | DNA methyltransferase 1 associated protein 1 |
| NCBI Official Symbol: | DMAP1 |
| NCBI Official Synonym Symbols: | EAF2; SWC4; MEAF2; DNMAP1; DNMTAP1 |
| NCBI Protein Information: | DNA methyltransferase 1-associated protein 1 |
| UniProt Protein Name: | DNA methyltransferase 1-associated protein 1 |
| Protein Family: | DNA methyltransferase 1-associated protein |
| UniProt Gene Name: | DMAP1 |
