Anti-CBR1 Antibody (CAB19263)

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SKU:
CAB19263
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CBR1
Synonyms:
CBR
Synonyms:
SDR21C1
Synonyms:
hCBR1
Synonyms:
carbonyl reductase 1
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Description

Product Name:CBR1 Rabbit mAb
Product Code:CAB19263
Size:20uL, 50uL, 100uL
Synonyms:CBR1, CBR, SDR21C1, hCBR1, carbonyl reductase 1
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human CBR1.
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, A-549, U-251MG, Mouse testis, Mouse brain
Immunogen:Recombinant protein of human CBR1.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:873
Uniprot:P16152
Cellular Location:Cytoplasm
Calculated MW:30kDa
Observed MW:33KDa
UniProt Protein Function:CBR1: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
UniProt Protein Details:

Protein type:EC 1.1.1.189; Lipid Metabolism - arachidonic acid; EC 1.1.1.197; Oxidoreductase; EC 1.1.1.184

Chromosomal Location of Human Ortholog: 21q22.13

Cellular Component: cytosol; vesicle

Molecular Function:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; prostaglandin-E2 9-reductase activity; 15-hydroxyprostaglandin dehydrogenase (NADP+) activity; carbonyl reductase (NADPH) activity

Biological Process: epithelial cell differentiation; vitamin K metabolic process; cyclooxygenase pathway; arachidonic acid metabolic process; drug metabolic process

NCBI Summary:The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
UniProt Code:P16152
NCBI GenInfo Identifier:118519
NCBI Gene ID:873
NCBI Accession:P16152.3
UniProt Secondary Accession:P16152,Q3LHW8, B2RBZ7, B4DFK7,
UniProt Related Accession:P16152
Molecular Weight:277
NCBI Full Name:Carbonyl reductase
NCBI Synonym Full Names:carbonyl reductase 1
NCBI Official Symbol:CBR1  
NCBI Official Synonym Symbols:CBR; hCBR1; SDR21C1  
NCBI Protein Information:carbonyl reductase [NADPH] 1; carbonyl reductase [NADPH] 1; carbonyl reductase (NADPH) 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase; NADPH-dependent carbonyl reductase 1; 15-hydroxyprostaglandin dehydrogenase; short chain dehydrogenase/reductase family 21C, member 1
UniProt Protein Name:Carbonyl reductase [NADPH] 1
UniProt Synonym Protein Names:15-hydroxyprostaglandin dehydrogenase [NADP(+)] (EC:1.1.1.197); NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase (EC:1.1.1.189)
Protein Family:Carbonyl reductase
UniProt Gene Name:CBR1  
UniProt Entry Name:CBR1_HUMAN
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