The Adenosine Deaminase (ADA) Antibody (CAB1019) is a high-quality antibody developed for reliable detection and analysis of target proteins. Raised in rabbits, this antibody is highly specific for human samples and has been validated for use in Western blot applications. It binds specifically to adenosine deaminase, allowing for precise detection and analysis in various cell types, making it ideal for studies in immunology and cancer research.Adenosine deaminase is a key enzyme in the purine salvage pathway, essential for maintaining immune function by regulating levels of adenosine, a molecule involved in inflammation and immune response modulation.
This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Rat samples.
Product Name:
Adenosine Deaminase (ADA) Antibody
SKU:
CAB1019
Size:
20μL, 100μL
Reactivity:
Human, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine in the purine catabolic pathway. Various mutations have been described for this gene and have been linked to human diseases related to impaired immune function such as severe combined immunodeficiency disease (SCID) which is the result of a deficiency in the ADA enzyme. In ADA-deficient individuals there is a marked depletion of T, B, and NK lymphocytes, and consequently, a lack of both humoral and cellular immunity. Conversely, elevated levels of this enzyme are associated with congenital hemolytic anemia.
Purification Method
Affinity purification
Gene ID
100
RRID
AB_2757711
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using Adenosine Deaminase (ADA) Rabbit pAb (CAB1019) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 5s.
Immunofluorescence analysis of U2OS cells using Adenosine Deaminase (ADA) Rabbit pAb (CAB1019) at dilution of 1:100. Blue: DAPI for nuclear staining.
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