ADCY5 Antibody (PACO19064)
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주문- SKU:
- PACO19064
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ADCY5 Antibody (PACO19064) |
Antibody SKU: | PACO19064 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human ADCY5 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19064(ADCY5 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19064(ADCY5 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs α subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi α subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. |
Synonyms: | adenylate cyclase 5 |
UniProt Protein Function: | ADCY5: This is a membrane-bound, calcium-inhibitable adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Adenylyl cyclase; Nucleotide Metabolism - purine; Transporter, aquaporin family; EC 4.6.1.1; Transporter; Membrane protein, integral; LyaseChromosomal Location of Human Ortholog: 3q21.1Cellular Component: integral to membrane; plasma membraneMolecular Function: adenylate cyclase activity; adenylate cyclase binding; protein heterodimerization activityBiological Process: activation of protein kinase A; adenylate cyclase activation; cAMP biosynthetic process; cAMP-mediated signaling; elevation of cytosolic calcium ion concentration; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; renal water homeostasisDisease: Dyskinesia, Familial, With Facial Myokymia |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
UniProt Code: | O95622 |
NCBI GenInfo Identifier: | 118572619 |
NCBI Gene ID: | 111 |
NCBI Accession: | O95622.3 |
UniProt Secondary Accession: | O95622,Q7RTV7, Q8NFM3, B7Z8A6 |
UniProt Related Accession: | O95622 |
Molecular Weight: | 102,606 Da |
NCBI Full Name: | Adenylate cyclase type 5 |
NCBI Synonym Full Names: | adenylate cyclase 5 |
NCBI Official Symbol: | ADCY5 |
NCBI Official Synonym Symbols: | AC5; FDFM |
NCBI Protein Information: | adenylate cyclase type 5 |
UniProt Protein Name: | Adenylate cyclase type 5 |
UniProt Synonym Protein Names: | ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5; AC5 |
Protein Family: | Adenylate cyclase |
UniProt Gene Name: | ADCY5 |
UniProt Entry Name: | ADCY5_HUMAN |