The XylT1 Polyclonal Antibody (PAC013270) is a valuable tool for researchers studying Xylosyltransferase 1 (XylT1), an enzyme involved in the biosynthesis of proteoglycans. This antibody, produced in rabbits, is highly specific to human XylT1 and is validated for use in Western blot applications. By targeting the XylT1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for investigations in glycobiology and extracellular matrix remodeling.XylT1 is a key player in the enzymatic pathway responsible for adding xylose to proteoglycans, a process crucial for proper cell signaling and matrix organization.
Dysregulation of XylT1 activity has been implicated in various diseases, including cancer and developmental disorders. By studying XylT1 expression and function, researchers can gain insights into how alterations in proteoglycan synthesis contribute to disease pathology and potentially identify therapeutic targets for intervention. The XylT1 Polyclonal Antibody is a valuable resource for advancing research in this important area of biology.
XYLT1: Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. Belongs to the glycosyltransferase 14 family. XylT subfamily.Protein type: Glycan Metabolism - heparan sulfate biosynthesis; Transferase; EC 2.4.2.26; Membrane protein, integral; Glycan Metabolism - chondroitin sulfate biosynthesisChromosomal Location of Human Ortholog: 16p12.3Cellular Component: Golgi membraneMolecular Function: protein xylosyltransferase activityBiological Process: glycosaminoglycan biosynthetic processDisease: Desbuquois Dysplasia 2; Pseudoxanthoma Elasticum
UniProt Protein Details:
NCBI Summary:
This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.[provided by RefSeq, Nov 2009]
