The VPRBP Polyclonal Antibody offered by AssayGenie is a valuable tool for researchers studying the VPRBP protein, which is involved in various cellular processes including protein degradation and gene regulation. This antibody is raised in rabbits and has been validated for use in Western blot applications, providing reliable detection and analysis of the VPRBP protein in human samples.VPRBP, also known as DCAF1, is a key component of the VPRBP-DDB1-CUL4 E3 ubiquitin ligase complex, which plays a crucial role in targeting specific proteins for degradation. Dysregulation of this complex has been linked to various diseases including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions.
By using the VPRBP Polyclonal Antibody, researchers can gain insights into the function and regulation of VPRBP in different cellular contexts, helping to further our understanding of its role in disease pathology. This antibody is an essential tool for studies in molecular biology, cell biology, and drug development, offering a versatile and reliable solution for researchers investigating the VPRBP protein.
Product Name:
VPRBP Polyclonal Antibody
SKU:
CAB24518
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1058-1396 of human VPRBP (NP_055518.1).
Enables estrogen receptor binding activity and histone kinase activity (H2A-T120 specific). Involved in cell competition in a multicellular organism; histone H2A-T120 phosphorylation; and negative regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. Part of Cul4-RING E3 ubiquitin ligase complex. Colocalizes with COP9 signalosome.
Purification Method:
Affinity purification
Gene ID:
9730
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using VPRBP Rabbit pAb (CAB24518) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
