The VEZT Antibody (PAC013175) is a polyclonal antibody designed for research involving VEZT, a protein involved in cell-cell adhesion and signaling. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications including immunofluorescence and immunohistochemistry. It specifically binds to the VEZT protein, allowing for detection and analysis in different cell types, making it a valuable tool for studies in cell biology and tissue organization.VEZT, also known as vezatin, plays a crucial role in maintaining tissue integrity and function by mediating interactions between cells.
Its involvement in cell adhesion and signaling pathways makes it a key player in processes like cell migration, cell communication, and tissue development. Research into VEZT can provide insights into mechanisms underlying diseases such as cancer, developmental disorders, and tissue abnormalities.By using the VEZT Antibody (PAC013175), researchers can explore the functions and regulation of VEZT in different cellular contexts, advancing our understanding of cell dynamics and contributing to the development of potential therapeutic strategies targeted at diseases involving dysregulated cell-cell interactions.
VEZATIN: Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. Belongs to the vezatin family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffold; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 12q22Cellular Component: acrosome; adherens junction; cytoplasm; integral to membrane; nucleoplasm; plasma membraneMolecular Function: myosin bindingBiological Process: cell-cell adhesion
UniProt Protein Details:
NCBI Summary:
This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
