TXN1 Recombinant Protein (RPPB5046)
- SKU:
- RPPB5046
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Target:
- TXN1
- Synonyms:
- Thioredoxin-1
- Trx-1
- trxA
- fipA
- Source:
- Escherichia Coli
- Uniprot:
- P0AA25
Description
| Product Name: | TXN1 Recombinant Protein |
| Product Code: | RPPB5046 |
| Size: | 10µg |
| Target: | TXN1 |
| Synonyms: | Thioredoxin-1, Trx-1, trxA, fipA, tsnC, b3781, JW5856. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The TRX His Tag protein solution contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MHHHHHHMGS DKIIHLTDDS FDTDVLKADG AILVDFWAEW CGPCKMIAPI LDEIADEYQG KLTVAKLNID QNPGTAPKYG IRGIPTLLLF KNGEVAATKV GALSKGQLKE FLDANLAGS |
Thioredoxins are small disulphide-containing redox proteins (within the conserved Cys-Gly-Pro-Cys active site) that have been found in all the kingdoms of living organisms. Thioredoxin contains a single disulfide active site and serves as a general protein disulphide oxidoreductase. Thioredoxins are involved in the first unique step in DNA synthesis. It interacts with a broad range of proteins by a redox mechanism based on reversible oxidation of two cysteine thiol groups to a disulphide, accompanied by the transfer of two electrons and two protons. The net result is the covalent interconversion of a disulphide and a dithiol. Trx also provides control over a number of transcription factors affecting cell proliferation and death through a mechanism referred to as redox regulation. It has been suggested that thioredoxin may catalyze the formation of correct disulfides during protein folding because of its ability to act as an efficient oxidoreductant. This could be especially useful in
Recombinant Thioredoxin produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids (2-109 a.a.) and having a molecular mass of 12.9kDa. TRX contains an amino acid His Tag N-terminus and is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P0AA25 |
| NCBI GenInfo Identifier: | 67005950 |
| NCBI Gene ID: | 23335415 |
| NCBI Accession: | NP_418228.2 |
| UniProt Secondary Accession: | P0AA25,P00274, P76750, Q2M889, Q47674, Q8XAT2 |
| UniProt Related Accession: | P0AA25 |
| Molecular Weight: | |
| NCBI Full Name: | thioredoxin 1 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | trxA |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | thioredoxin |
| UniProt Protein Name: | Thioredoxin-1 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Thioredoxin |
| UniProt Gene Name: | trxA |
| UniProt Entry Name: | THIO_ECOLI |
Related Products
