Description
TMPO Antibody (PACO12813)
The TMPO Polyclonal Antibody (PAC012813) is a valuable tool for researchers studying the nuclear envelope protein, TMPO. TMPO plays a crucial role in maintaining the structure and function of the nucleus, making it a key player in various cellular processes such as DNA replication and gene expression. This rabbit-derived antibody is highly specific to human TMPO and has been validated for use in Western blot applications. By binding to TMPO, researchers can easily detect and analyze the protein in different cell types, allowing for in-depth studies in fields such as cell biology and genetics.
Given the importance of TMPO in nuclear organization and genome stability, research involving this protein has significant implications in understanding diseases such as cancer and genetic disorders. By utilizing the TMPO Polyclonal Antibody, scientists can delve deeper into the mechanisms underlying these conditions and potentially identify new therapeutic targets.
| Antibody Name: | TMPO Antibody (PACO12813) |
| Antibody SKU: | PACO12813 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human TMPO |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | thymopoietin;TMPO;CMD1T;LAP2;LEMD4;MGC61508;PRO0868;TP ; |
| UniProt Protein Function: | TMPO iso6: a single-pass type II membrane protein. Tightly associated with the nuclear lamina. Binds DNA and involved in DNA replication and chromatin remodeling, May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with HAP95. Associated with dilated cardiomyopathy; upregulated in medulloblastoma. Used as a pharmaceutical to treat primary and secondary immune deficiencies, autoimmunity, infections and cancer. Available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) and Mepentil (Recordati). Three alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:DNA-binding; Membrane protein, integral Chromosomal Location of Human Ortholog: 12q22 Cellular Component: chromatin; nuclear envelope; nucleus Molecular Function:lamin binding Disease: Cardiomyopathy, Dilated, 1t |
| NCBI Summary: | The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 2010] |
| UniProt Code: | P42166 |
| NCBI GenInfo Identifier: | 1174689 |
| NCBI Gene ID: | 7112 |
| NCBI Accession: | P42166.2 |
| UniProt Secondary Accession: | P42166,P08918, P08919, Q14860, Q16295, |
| UniProt Related Accession: | P42166,P42167 |
| Molecular Weight: | 50,670 Da |
| NCBI Full Name: | Lamina-associated polypeptide 2, isoform alpha |
| NCBI Synonym Full Names: | thymopoietin |
| NCBI Official Symbol: | TMPO |
| NCBI Official Synonym Symbols: | TP; LAP2; CMD1T; LEMD4; PRO0868 |
| NCBI Protein Information: | thymopoietin |
| UniProt Protein Name: | Lamina-associated polypeptide 2, isoform alpha |
| UniProt Synonym Protein Names: | Thymopoietin isoform alpha; TP alpha |
| Protein Family: | Lamina-associated polypeptide |
| UniProt Gene Name: | TMPO |
| UniProt Entry Name: | LAP2A_HUMAN |