The TIMM13 Polyclonal Antibody (CAB23597) is a valuable tool for researchers studying the TIMM13 protein, a key component of the mitochondrial import machinery involved in protein translocation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blotting applications. By specifically binding to the TIMM13 protein, researchers can effectively detect and analyze this important mitochondrial protein in various cell types.TIMM13 is essential for the proper functioning of mitochondria, playing a crucial role in the import of nuclear-encoded proteins into these organelles.
Dysfunction of TIMM13 has been implicated in various mitochondrial disorders and diseases, making it a promising target for further investigation in the fields of cell biology and metabolic research. By gaining a better understanding of how TIMM13 functions, researchers can develop potential therapies for mitochondrial-related conditions and disorders.
Product Name:
TIMM13 Polyclonal Antibody
SKU:
CAB23597
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-95 of human TIMM13（NP_036590.1）.
This gene encodes a member of the evolutionarily conserved TIMM (translocase of inner mitochondrial membrane) family of proteins that function as chaperones in the import of proteins from the cytoplasm into the mitochondrial inner membrane. Proteins of this family play a role in collecting substrate proteins from the translocase of the outer mitochondrial membrane (TOM) complex and delivering them to either the sorting and assembly machinery in the outer mitochondrial membrane (SAM) complex or the TIMM22 complex in the inner mitochondrial membrane. The encoded protein and the translocase of mitochondrial inner membrane 8a protein form a 70 kDa complex in the intermembrane space.
Purification Method:
Affinity purification
Gene ID:
26517
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat kidney, using TIMM13 Rabbit pAb (CAB23597) at 1:4000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
