The TIM44 Monoclonal Antibody is a crucial tool for researchers studying TIM44, a protein involved in mitochondrial biogenesis and protein import. This monoclonal antibody, produced in mice, exhibits high specificity and sensitivity for detecting TIM44 in various experimental settings such as Western blotting and immunofluorescence.TIM44 is a key player in the maintenance of mitochondrial function and has been linked to various human diseases including neurodegenerative disorders and metabolic syndromes. By targeting TIM44 with this antibody, researchers can gain valuable insights into the mechanisms underlying mitochondrial dysfunction and potentially identify novel therapeutic targets for these diseases.
Overall, the TIM44 Monoclonal Antibody is an essential reagent for scientists investigating mitochondrial biology and seeking to unravel the complex roles of TIM44 in health and disease. Its reliability and versatility make it a valuable asset in the fields of cell biology, biochemistry, and mitochondrial research.
Product Name:
TIM44 Monoclonal Antibody
SKU:
CAB21141
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 10-240 of human TIM44 (NP_006342.2).
fibrillar center, mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Calculated MW:
51kDa
Observed MW:
45kDa
This gene encodes a peripheral membrane protein associated with the mitochondrial inner membrane translocase, which functions in the import of proteins across the mitochondrial inner membrane and into the mitochondrial matrix. The encoded protein mediates binding of mitochondrial heat shock protein 70 to the translocase of inner mitochondrial membrane 23 (TIM23) complex. Expression of this gene is upregulated in kidney in a mouse model of diabetes. A mutation in this gene is associated with familial oncocytic thyroid carcinoma.
Purification Method:
Affinity purification
Gene ID:
10469
Clone Number:
ARC3044
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using TIM44 Rabbit mAb (CAB21141) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
