The TECR Polyclonal Antibody (PACO03182) is a valuable tool for researchers studying TECR, an enzyme involved in lipid metabolism and cell membrane synthesis. This antibody, raised in rabbits, is highly specific for TECR in human samples and is validated for use in Western blot applications. By detecting and analyzing TECR expression in various cell types, this antibody is essential for investigations in biochemistry and cell biology.TECR, also known as tetratricopeptide repeat domain 8 (Ttc8), plays a crucial role in maintaining lipid homeostasis and cell membrane integrity. Dysregulation of TECR has been linked to lipid metabolism disorders and related diseases, making it a promising target for therapeutic interventions.
Understanding the function of TECR is essential for developing treatments for metabolic syndromes and other lipid-related conditions.Researchers interested in lipid metabolism, cell membrane synthesis, and related diseases will benefit greatly from using the TECR Polyclonal Antibody (PACO03182) in their studies. Its high specificity and reliability make it a valuable asset for advancing our understanding of TECR's role in cellular processes and disease pathways.
Antibody Name:
TECR Antibody
Antibody SKU:
PACO03182
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the C-terminal region of human GPSN2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
GPSN2: Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids. Defects in TECR are the cause of mental retardation autosomal recessive type 14 (MRT14). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the steroid 5-alpha reductase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.3.1.93; Membrane protein, integral; Oxidoreductase; Membrane protein, multi-pass; Lipid Metabolism - unsaturated fatty acid biosynthesisChromosomal Location of Human Ortholog: 19p13.12Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; nucleusMolecular Function: oxidoreductase activity, acting on the CH-CH group of donors; protein bindingBiological Process: cellular lipid metabolic process; fatty acid elongation; triacylglycerol biosynthetic process; very-long-chain fatty acid biosynthetic processDisease: Mental Retardation, Autosomal Recessive 14
UniProt Protein Details:
NCBI Summary:
This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]
