Description
TASP1 Antibody (PACO12641)
The TASP1 Polyclonal Antibody (PAC012641) is a valuable tool for researchers investigating the role of TASP1, a crucial protein involved in DNA repair and cell cycle regulation. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the TASP1 protein, this antibody allows for accurate detection and analysis in various cell types, making it an ideal choice for studies in molecular biology, cancer research, and genomic stability.TASP1, also known as Threonine Aspartase 1, is a key player in the DNA damage response pathway, playing a critical role in repairing DNA breaks and maintaining genomic integrity. Dysregulation of TASP1 has been linked to various cancers and genetic disorders, highlighting its importance in cellular functions.
By studying the function and regulation of TASP1, researchers can gain valuable insights into the mechanisms of DNA repair and potential therapeutic strategies for diseases associated with genomic instability.Overall, the TASP1 Polyclonal Antibody is a reliable tool for investigating the functions of TASP1 and its implications in DNA repair, cell cycle control, and disease development. Its high specificity and reactivity make it an essential component for research projects aiming to elucidate the molecular mechanisms underlying genomic stability and cellular homeostasis.
| Antibody Name: | TASP1 Antibody (PACO12641) |
| Antibody SKU: | PACO12641 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human TASP1 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | taspase, threonine aspartase, 1;TASP1;C20orf13;FLJ20212;MGC39159;dJ585I14.2 ; |
| UniProt Protein Function: | TASP1: Protease involved in MLL processing and, consequently, in the correct expression of the early HOXA gene cluster. Belongs to the Ntn-hydrolase family. |
| UniProt Protein Details: | Protein type:EC 3.4.25.-; Protease Chromosomal Location of Human Ortholog: 20p12.1 Molecular Function:threonine endopeptidase activity Biological Process: positive regulation of transcription, DNA-dependent; proteolysis |
| NCBI Summary: | This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H6P5 |
| NCBI GenInfo Identifier: | 29839766 |
| NCBI Gene ID: | 55617 |
| NCBI Accession: | Q9H6P5.1 |
| UniProt Secondary Accession: | Q9H6P5,Q5TDU9, Q9BQN0, Q9NQ08, Q9NTS6, Q9NXJ2, B7Z690 B7Z963, |
| UniProt Related Accession: | Q9H6P5 |
| Molecular Weight: | 420 |
| NCBI Full Name: | Threonine aspartase 1 |
| NCBI Synonym Full Names: | taspase, threonine aspartase, 1 |
| NCBI Official Symbol: | TASP1 |
| NCBI Official Synonym Symbols: | C20orf13; dJ585I14.2 |
| NCBI Protein Information: | threonine aspartase 1; taspase 1; taspase-1 |
| UniProt Protein Name: | Threonine aspartase 1 |
| Protein Family: | Threonine aspartase |
| UniProt Gene Name: | TASP1 |
| UniProt Entry Name: | TASP1_HUMAN |
