| UniProt Protein Function: | SPTLC3: Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SSSPTA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SSSPTB has the ability to use a broader range of acyl-CoAs without apparent preference. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 2.3.1.50; Endoplasmic reticulum; Transferase; Membrane protein, integralChromosomal Location of Human Ortholog: 20p12.1Cellular Component: endoplasmic reticulum membraneMolecular Function: serine C-palmitoyltransferase activityBiological Process: sphingoid biosynthetic process; sphingolipid biosynthetic process |
| UniProt Protein Details: | |
| NCBI Summary: | The SPTLC3 gene encodes an isoform of the third subunit of serine palmitoyltransferase (SPT; EC 2.3.1.50), which catalyzes the rate-limiting step of the de novo synthesis of sphingolipids (Hornemann et al., 2006 [PubMed 17023427]). SPT contains 2 main subunits: the common SPTLC1 subunit (MIM 605712) and either SPTLC2 (MIM 605713) or its isoform SPTLC2L (SPTLC3), depending on the tissue in which biosynthesis occurs (Hornemann et al., 2006 [PubMed 17023427]). There are also 2 highly related isoforms of a third subunit, SSSPTA (MIM 613540) and SSSPTB (MIM 610412), that confer acyl-CoA preference of the SPT enzyme and are essential for maximal enzyme activity (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010] |
| UniProt Code: | Q9NUV7 |
| NCBI GenInfo Identifier: | 158931158 |
| NCBI Gene ID: | 55304 |
| NCBI Accession: | Q9NUV7.3 |
| UniProt Secondary Accession: | Q9NUV7,Q05DQ8, Q5T1U4, Q9H1L1, Q9H1Z0, A2A2I4, B9EK64 |
| UniProt Related Accession: | Q9NUV7 |
| Molecular Weight: | 19,693 Da |
| NCBI Full Name: | Serine palmitoyltransferase 3 |
| NCBI Synonym Full Names: | serine palmitoyltransferase long chain base subunit 3 |
| NCBI Official Symbol: | SPTLC3 |
| NCBI Official Synonym Symbols: | LCB3; SPT3; LCB2B; hLCB2b; SPTLC2L; C20orf38; dJ718P11; dJ718P11.1 |
| NCBI Protein Information: | serine palmitoyltransferase 3 |
| UniProt Protein Name: | Serine palmitoyltransferase 3 |
| UniProt Synonym Protein Names: | Long chain base biosynthesis protein 2b; LCB2b; Long chain base biosynthesis protein 3; LCB 3; Serine-palmitoyl-CoA transferase 3; SPT 3 |
| Protein Family: | Serine palmitoyltransferase |
| UniProt Gene Name: | SPTLC3 |
| UniProt Entry Name: | SPTC3_HUMAN |
