SOX4 Antibody (PACO65157)

1. The results of the present study demonstrated that miR30a5p suppressed the proliferation, migration and invasion of melanoma cells in SOX4dependent manner PMID: 29901141
2. The results of the present study indicated that miR188 suppressed pediatric osteosarcoma progression by targeting SOX4. PMID: 29749512
3. This revealed that the overexpression of p65 partially reversed SOX4 downregulation-induced apoptosis. In conclusion, our results demonstrated that inhibition of SOX4 markedly induced melanoma cell apoptosis via downregulation of the NF-kappaB signaling pathway, which thus may be a novel approach for the treatment of melanoma. PMID: 29767266
4. The expression level of Sox4 correlates with HCC development, clinical severity and prognosis of patients. LncSox4 interacts with and recruits Stat3 to the Sox4 promoter to initiate the expression of Sox4, which is highly expressed in liver tumor-initiating cells (TICs) and required for liver TIC self-renewal. PMID: 27553854
5. Our study offers evidence for the first time that lncSox4 plays a positive role in osteosarcoma development and progression, and could act as a potential prognostic and therapy biomarker. PMID: 29441981
6. BG981369 and SOX4 are potentially effective therapeutic targets for GC. PMID: 29398692
7. results identify SOX4 as a transcription factor that is uniquely sensitive to cellular tension and indicate that TRPM7 may contribute to breast cancer progression by tensional regulation of SOX4. PMID: 29684587
8. High SOX4 expression is associated with gastric cancer. PMID: 28656304
9. CCAT1/miR-130a-3p axis enhanced cisplatin resistance of non-small-cell lung cancer (NSCLC) cells by targeting SOX4, providing potential targets to overcome cisplatin resistance and improve efficacy of chemotherapy for patients with NSCLC PMID: 29020498
10. High SOX4 expression is associated with invasion of renal cell carcinoma by inducing epithelial-mesenchymal transition. PMID: 28534986
11. findings indicate that SOX4 promotes melanoma cell migration and invasion through the activation of the NF-kappaB/p65 signaling pathway. PMID: 28627651
12. our study indicated a HAS1-miR214-SOX-4 pathway in regulating the growth and metastasis of Esophageal squamous cell carcinoma (ESCC) , providing a promising target for ESCC therapy PMID: 28656277
13. miRNA253p may act as a tumor suppressor by targeting SOX4 expression in bone tissue. PMID: 28765961
14. Studied upregulation of long noncoding RNA (lncRNA) HOXD-AS1 in liver cancer. Found STAT3 could combine to the promoter of HOXD-AS1 and activate the transcription of HOXD-AS1, and further found evidence that lncRNA HOXDAS1 shared miRNA response elements with SOX4, facilitating liver cancer metastasis. PMID: 28810927
15. our data indicated that miR-212 functions as a tumor-suppressor gene by regulating EMT and metastasis of non-small cell lung cancer (NSCLC)by targeting SOX4 signaling, and may represent a novel potential therapeutic target and prognostic marker for NSCLC. PMID: 28791372
16. CASC15 enhances YY1-mediated regulation of the SOX4 promoter. PMID: 28724437
17. Moreover, TUG1 knockdown suppressed proliferation and promoted apoptosis by upregulating miR-132-3p and downregulating SOX4 in primary OS cells. PMID: 29436190
18. SOX4 overexpression is associated with metastasis of nasopharyngeal carcinoma. PMID: 28504814
19. Data indicate a role for the miR-320/SOX4/FOXM1/FOXQ1 axes in promoting colorectal cancer (CRC) development and suggest targeting those networks as potential therapeutic strategy for CRC. PMID: 27119506
20. these data establish a role for SOX4-mediated PI3K/Akt signaling in breast cancer and suggest that SOX4 may represent a novel therapeutic target and/or biomarker for current PI3K family therapies. PMID: 28176176
21. High SOX4 expression is associated with melanoma. PMID: 27105574
22. microRNA-449 family acts as a tumor suppressor in liver cancer by causing cell death and inhibiting cell migration. These effects are caused by downregulation of the oncogene SOX4. PMID: 28088579
23. Study assessed the expression levels of nuclear SOX4 in colon tissues obtained from 263 patients with colon cancer. Immunoblotting results confirmed that nuclear SOX4 expression was higher in colon cancer cells than in normal colon cells. Overexpression of nuclear SOX4 in colon cancer tissues was closely correlated with tumor invasion and metastasis. PMID: 23826209
24. detailed analyses of the 6p22 amplicon suggest SOX4 as an auxiliary target gene for amplification. We further demonstrate three separate target regions for amplification at 1q21-24 and identified BCL9, CHD1L, and MCL1, SETDB1, and HIF1B as putative target genes within these regions PMID: 23825644
25. This work highlights the importance of the p53-miR-191-SOX4 axis in the regulation of apoptosis and doxorubicin resistance in breast cancer cell lines (MCF7 and ZR-75) PMID: 28450532
26. SOX4 overexpression rescued miR-25-induced suppression of proliferation, migration, and invasion of osteosarcoma cells. Taken together, these results suggest that miR-25 functions as a tumor suppressor in the progression of osteosarcoma by repressing SOX4. PMID: 28705117
27. our findings lead us to propose that TMEM2 may not only mediate the pathologic effects of SOX4 on cancer progression but also potentially its contributions to embryonic development PMID: 27328729
28. The cisplatin-resistance significantly decreased in A549/DDP cells after knockdown of SOX4 by siRNA transfection. PMID: 28532536
29. This study provided evidence that SOX4 could serve as a potential therapeutic target in prostate cancer PMID: 28466783
30. Findings suggest that miR-140 directly inhibits SOX4, which might be one of its mechanisms in suppressing gastric cancer cell proliferation. PMID: 27353653
31. UCA1 regulated Sox4 expression through functioning as a competing endogenous RNA (ceRNA). UCA1 directly interacted with miR-204 and decreased the binding of miR-204 to Sox4 3'UTR, which suppressed the degradation of Sox4 mRNA by miR-204. PMID: 27667646
32. SOX4 messenger RNA (mRNA) and protein expression were markedly higher in CRC tissues. PMID: 26768610
33. In this study we screened the transcriptional profiles of 70 MCL patients for SOXC cluster and miR17, miR18a, miR19b and miR92a, from the miR-17-92 cluster. Gene expression analysis showed higher SOX11 and SOX12 levels compared to SOX4 (P PMID: 26998831
34. These findings examined the important role of miR-204 and SOX4 played in gastric cancer, and they could be used as candidate therapeutic targets for gastric cancer therapy. PMID: 28133610
35. Overexpression of Sox4 is associated with a poor prognosis of osteosarcoma. PMID: 27072961
36. SOX4 was over-expressed in diffusely infiltrating astrocytomas and its expression was positively correlated with astrocytoma grade PMID: 26096696
37. Sox4 is a potential prognostic biomarker in human cancers.[review; meta-analysis] PMID: 26250764
38. miR-211 could inhibit gastric cancer cell proliferation and invasion partially by down-regulating SOX4. PMID: 26823713
39. data show that Sox4 is an important regulator of the bladder CSC properties and it may serve as a biomarker of the aggressive phenotype in bladder cancer PMID: 26681916
40. Results suggested that SOX4 functions to modulate cancer proliferation by regulation of cell cycle, and inhibit cancer cell sensitivity to therapeutic drug via upregulation of ABCG2. PMID: 26583330
41. Sox4 was also able to promote b-catenin-mediated transcription of the Slug gene through formation of transcriptional complexes with b-catenin and p300, independent of TCF4 status PMID: 26841870
42. The miR-335 expression was inversely correlated with Sox4 expression in the identical clinical specimens, but it was not related to the prognosis. Sox4/Ezh2 axis was closely associated with the prognosis in pancreatic cancer patients PMID: 26648239
43. Sox4 enhances chondrogenic differentiation and proliferation of human synovium-derived stem cell via activation of long noncoding RNA DANCR PMID: 26514989
44. These findings revealed that miR338-3p may act as a tumor suppressor in breast cancer by targeting SOX4 PMID: 26252944
45. Our findings indicated that miR-204 negatively regulates SOX4 and inhibited proliferation, migration and invasion of T-cell acute lymphoblastic leukaemia cell lines. PMID: 26464665
46. miR132 inhibited cell growth and metastasis in osteosarcoma cells by downregulation of Sox4, and knockdown of Sox4 was essential for the miR-132-inhibited cell growth and metastasis in osteosarcoma cells PMID: 26352673
47. KLF5/Sox4 regulatory signaling play an important role in lung tumorigenesis, which might represent novel therapeutic targets to manage lung carcinoma. PMID: 24401325
48. SOX4 expression was induced by Pten loss as a result of the activation of PI3K-AKT-mTOR signaling PMID: 26701805
49. Overexpression of SOX4 correlates with clinical stages in nasopharyngeal carcinoma and promotes cell migration of CNE2 cells. PMID: 26578818
50. SOX4 may contribute to oncogenic phenotypes of head and neck squamous cell carcinoma cells by promoting cell survival and causing chemoradioresistance. It could be a potential prognostic marker for oral squamous cell carcinoma . PMID: 26555193

HGNC: 11200

OMIM: 184430

KEGG: hsa:6659

STRING: 9606.ENSP00000244745

UniGene: Hs.643910