The SNX8 Polyclonal Antibody (PAC017139) is a valuable tool for researchers studying SNX8, a key player in intracellular trafficking and protein sorting. This antibody, generated in rabbits, is highly specific to human samples and is validated for use in various experimental applications, including Western blotting. By binding to the SNX8 protein, this antibody enables researchers to detect and analyze SNX8 expression levels in different cell types, making it essential for studies in cell biology and molecular biology research.SNX8, also known as Sorting Nexin 8, is involved in the sorting and recycling of membrane proteins within cells, contributing to cellular processes such as endocytosis and endosomal trafficking.
Its role in regulating protein trafficking makes it a crucial target for investigating cellular pathways and functions. Research on SNX8 is important for understanding the mechanisms of various diseases, including neurodegenerative disorders, cancer, and metabolic conditions.By utilizing the SNX8 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of SNX8 in cellular processes and disease pathways, ultimately contributing to the development of novel therapeutic strategies and treatments targeting SNX8-related disorders.
Antibody Name:
SNX8 Antibody (PACO17139)
Antibody SKU:
PACO17139
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human SNX8
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17139(SNX8 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17139(SNX8 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Sorting nexin (SNX) proteins are members of a large family of hydrophilic PX (phospholipid-binding motif) domain-containing proteins that interact with a variety of receptor types. SNXs are widely expressed, although the tissue distribution of each SNX mRNA varies. The ability of SNXs to bind specific phospholipids, as well as their tendency to form protein-protein complexes, suggests a role for these proteins in cellular membrane trafficking and protein sorting. SNXs may also function specifically in pro-degradative sorting, internalization, endosomal recycling or simply in endosomal sorting. SNXs partially associate with cellular membranes, despite their hydrophilic nature. SNX8 is an ortholog of a yeast protein.
Synonyms:
sorting nexin 8
UniProt Protein Function:
SNX8: May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network. Belongs to the sorting nexin family.Chromosomal Location of Human Ortholog: 7p22.3Cellular Component: early endosome membrane; extrinsic to membrane; intracellular membrane-bound organelle; retromer complexMolecular Function: identical protein binding; phosphoinositide binding; protein bindingBiological Process: endocytosis; intracellular protein transport; vesicle organization and biogenesis
