The SMG1 Polyclonal Antibody (CAB10006) is a high-quality antibody designed for researchers studying SMG1, a key protein involved in mRNA surveillance and nonsense-mediated mRNA decay (NMD). This rabbit polyclonal antibody has been validated for use in various applications, including Western blotting and immunohistochemistry.SMG1 is a crucial component of the NMD pathway, which helps to degrade faulty mRNA transcripts and maintain the integrity of the cellular transcriptome. Dysregulation of this pathway has been linked to various human diseases, including neurological disorders and cancer. By using the SMG1 Polyclonal Antibody, researchers can better understand the role of SMG1 in mRNA quality control and potentially uncover new therapeutic targets for treating RNA-related diseases.
This antibody offers high sensitivity and specificity in detecting SMG1 protein levels in cell lysates and tissue samples, making it an essential tool for investigating the molecular mechanisms underlying mRNA decay pathways. With its proven performance in research studies, the SMG1 Polyclonal Antibody is a valuable resource for scientists conducting cutting-edge research in the fields of molecular biology and RNA biology.
Product Name:
SMG1 Polyclonal Antibody
SKU:
CAB21169
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SMG1 (NP_055907.3).
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined.
Purification Method:
Affinity purification
Gene ID:
23049
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunofluorescence analysis of NIH/3T3 cells using SMG1 Rabbit pAb (CAB21169) at dilution of 1:200 (40x lens). Blue: DAPI for nuclear staining.
