The SLC5A4 Polyclonal Antibody (PACO59968) is a valuable tool for researchers studying the SLC5A4 protein, a key transporter involved in glucose and electrolyte transport in the kidneys. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.SLC5A4, also known as sodium/glucose cotransporter 4, plays a crucial role in the reabsorption of glucose and sodium in the kidneys, helping to maintain proper electrolyte balance and glucose levels in the body. Dysregulation of SLC5A4 has been implicated in various kidney disorders and metabolic conditions, making it an important target for research in nephrology and endocrinology.
By using the SLC5A4 Polyclonal Antibody, researchers can effectively detect and analyze SLC5A4 protein expression in different cell types and tissues, aiding in the investigation of its function and potential therapeutic applications. Understanding the mechanisms underlying SLC5A4-mediated transport processes is essential for developing targeted interventions for kidney and metabolic diseases.
Antibody Name:
SLC5A4 Antibody (PACO59968)
Antibody SKU:
PACO59968
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Solute carrier family 5 member 4 protein (579-633AA)
Immunofluorescence staining of HepG2 cells with PACO59968 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Sodium-dependent glucose transporter.
Synonyms:
Solute carrier family 5 member 4, SLC5A4, SAAT1 SGLT3
UniProt Protein Function:
SLC5A4: Sodium-dependent glucose transporter. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.Protein type: Transporter; Channel, ligand-gated; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 22q12.3Cellular Component: integral to plasma membraneMolecular Function: glucose:sodium symporter activityBiological Process: sodium ion transport
