SIRPB1 Antibody (PACO46202)
- SKU:
- PACO46202
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | SIRPB1 Antibody (PACO46202) |
| Antibody SKU: | PACO46202 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Signal-regulatory protein beta-1 protein (30-371AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: SIRPB1 antibody at 6µg/ml. Lane 1: A549 whole cell lysate. Lane 2: PC-3 whole cell lysate. Lane 3: A375 whole cell lysate. Lane 4: Mouse heart tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 44, 20 kDa. Observed band size: 44 kDa.. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO46202 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO46202 at dilution of 1:100. |
| Background: | Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. |
| Synonyms: | Signal-regulatory protein beta-1 (SIRP-beta-1) (CD172 antigen-like family member B) (CD antigen CD172b), SIRPB1 |
| UniProt Protein Function: | SIRPB1: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 20p13Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: protein bindingBiological Process: cell surface receptor linked signal transduction; innate immune response; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
| UniProt Code: | O00241 |
| NCBI GenInfo Identifier: | 311033545 |
| NCBI Gene ID: | 10326 |
| NCBI Accession: | O00241.5 |
| UniProt Secondary Accession: | O00241,Q5TFQ9, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0, A6NLM2 B2R8V0 |
| UniProt Related Accession: | O00241,Q5TFQ8, O00241 |
| Molecular Weight: | 43,359 Da |
| NCBI Full Name: | Signal-regulatory protein beta-1 |
| NCBI Synonym Full Names: | signal regulatory protein beta 1 |
| NCBI Official Symbol: | SIRPB1 |
| NCBI Official Synonym Symbols: | CD172b; SIRP-BETA-1 |
| NCBI Protein Information: | signal-regulatory protein beta-1 |
| UniProt Protein Name: | Signal-regulatory protein beta-1 |
| UniProt Synonym Protein Names: | CD172 antigen-like family member B; CD_antigen: CD172b |
| Protein Family: | Signal-regulatory protein |
| UniProt Gene Name: | SIRPB1 |
| UniProt Entry Name: | SIRB1_HUMAN |
| Antibodies |
| SIRPB1 Antibody (PACO00549) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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