The SFT Monoclonal Antibody is a valuable tool for researchers studying SFT, a protein involved in immune regulation and immune response inhibition. This antibody, produced through monoclonal techniques, is highly specific and reactive with human samples, making it ideal for Western blot applications. By binding to the SFT protein, this antibody enables precise detection and analysis in various cell types, making it a critical tool for studies in immunology and cancer research.SFT, also known as immune inhibitory factor, plays a crucial role in maintaining immune homeostasis by regulating inflammatory responses and suppressing allergic reactions.
Its potential in modulating immune responses highlights its significance as a target for research in diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the mechanisms of SFT activity is essential for developing novel therapies that target or manipulate immune function in these disease contexts.
Product Name:
SFT Monoclonal Antibody
SKU:
CAB21076
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-147 of human SFT (NP_003329.1).
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7321
Clone Number:
ARC2935
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma using SFT Rabbit mAb (CAB21076) at dilution of 1:50 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
