Description
| Product Name: | Recombinant Human LMP2 (HLA-A*11:01) Tetramer Protein |
| SKU: | RPCB1626 |
| Size: | 100µg |
| Tag: | C-His&Avi |
| Reactivity: | Human |
| Expression Host: | HEK293 cells |
| Protein Description: | High quality, high purity and low endotoxin recombinant Recombinant Human LMP2(HLA-A*11:01) Tetramer Protein , tested reactivity in HEK293 cells and has been validated in SDS-PAGE.100% guaranteed. |
| Endotoxin: | Less than 1EU per μg by the LAL method. |
| Purity: | > 95% as determined by Tris-Bis PAGE；> 95% as determined by HPLC |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of malignant tumors that highly express LMP2.
| Storage: | Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. |
| Reconstitution: | Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles. |
| Swiss-Prot: | AAV53343.1(HLA-A*11:01)&P61769(B2M)&SSCSSCPLTK |
 | Human LMP2 (HLA-A*11:01) Tetramer on Tris-Bis PAGE under Non reducing (N) condition. The purity is greater than 95%. |
 | The purity of Human LMP2 (HLA- A*11:01) Tetramer is greater than 95% as determined by SEC-HPLC. |
