Recombinant Human GITR/TNFRSF18 Protein (Fc Tag) (RPES8378)
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- SKU:
- RPES8378
- Size:
- 20μg
- Tag:
- C-Fc
- Reactivity:
- Human
- Expression Host:
- Mammalian
- Accession:
- Q9Y5U5
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Description
| Product Name: | Recombinant Human GITR/TNFRSF18 Protein (Fc Tag) |
| SKU: | RPES8378 |
| Size: | 20μg |
| Tag: | C-Fc |
| Reactivity: | Human |
| Expression Host: | Mammalian |
| Accession: | Q9Y5U5 |
| Sequence: | Gln26-Glu161 |
| Calculated Molecular Weight: | 39.9 kDa |
| Observed Molecular Weight: | 45 kDa |
| Synonyms: | UNQ, PRO, Tumor necrosis factor receptor superfamily member, Tnfrsf, CD357, Glucocorticoid-induced TNFR-related protein, Tumor necrosis factor receptor superfamily member 18, AITR, GITR, TNFRSF18, UNQ319, PRO364, GITR, AITR |
| Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
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