Recombinant Human Aminoacylase 1/ACY 1 Protein (RPCB1887)
- SKU:
- RPCB1887
- Size:
- 50µg
- Tag:
- C-His
- Reactivity:
- Human
- Expression Host:
- Baculovirus-Insect Cells
Description
| Product Name: | Recombinant Human Aminoacylase 1/ACY 1 Protein |
| SKU: | RPCB1887 |
| Size: | 50µg |
| Tag: | C-His |
| Reactivity: | Human |
| Expression Host: | Baculovirus-Insect Cells |
| Protein Description: | High quality, high purity and low endotoxin recombinant Recombinant Human Aminoacylase 1/ACY 1 Protein , tested reactivity in Baculovirus-Insect Cells and has been validated in SDS-PAGE.100% guaranteed. |
| Endotoxin: | < 1.0 EU per μg of the protein as determined by the LAL method |
| Purity: | > 95 % as determined by SDS-PAGE |
| Formulation: | Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0, 10% glycerol |
| Gene ID: | 95 |
Aminoacylase 1 (ACY1), a metalloenzyme that removes amide-linked ACY1 groups from amino acids and may play a role in regulating responses to oxidative stress. Both the C-terminal fragment found in the two-hybrid screen and full-length ACY1 co-immunoprecipitate with SphK1. Though both C-terminal and full-length proteins slightly reduce SphK1 activity measured in vitro, the C-terminal fragment inhibits while full-length ACY1 potentiates the effects of SphK1 on proliferation and apoptosis. It suggested that ACY1 physically interacts with SphK1 and may influence its physiological functions. As a homodimeric zinc-binding enzyme, Aminoacylase 1 catalyzes the hydrolysis of N alpha-acylated amino acids. Deficiency of Aminoacylase 1 due to mutations in the Aminoacylase 1 (ACY1) gene follows an autosomal-recessive trait of inheritance and is characterized by accumulation of N-acetyl amino acids in the urine.
| Storage: | Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. |
| Swiss-Prot: | Q03154 |
 | Recombinant Human Aminoacylase 1 Protein was determined by SDS- PAGE with Coomassie Blue, showing a band at 45 kDa. |
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