Recombinant Human ALK-1 Protein (Fc Tag) (RPES8348)
- SKU:
- RPES8348
- Size:
- 20μg
- Tag:
- C-Fc
- Reactivity:
- Human
- Expression Host:
- Mammalian
- Accession:
- P37023
Frequently bought together:
Description
| Product Name: | Recombinant Human ALK-1 Protein (Fc Tag) |
| SKU: | RPES8348 |
| Size: | 20μg |
| Tag: | C-Fc |
| Reactivity: | Human |
| Expression Host: | Mammalian |
| Accession: | P37023 |
| Sequence: | Asp22-Gln118 |
| Calculated Molecular Weight: | 35.5 kDa |
| Observed Molecular Weight: | 50 kDa |
| Synonyms: | SKR, ORW, Activin Receptor-Like Kinase, Serine/Threonine-Protein Kinase Receptor R, ACVRL, ACVRLK, ALK, ACVRL1, ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I, Activin Receptor-Like Kinase 1, Serine/Threonine-Protein Kinase Receptor R3, TGF-B Superfamily Receptor Type I |
| Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
Activin A receptor , type II-like 1 (ACVRL1) , also known as ALK-1 (activin receptor-like kinase 1) , is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding , a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney , spleen , heart and intestine , serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2 , also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
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