| UniProt Protein Function: | CdGAP: Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. Interacts with ITSN1, which inhibits GAP activity. Interacts with PARVA. Interacts with GTP-loaded RHOU.Protein type: GAPs; GAPs, Rac/RhoChromosomal Location of Human Ortholog: 3q13.33Cellular Component: cytosol; lamellipodiumMolecular Function: GTPase activator activityBiological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transductionDisease: Adams-oliver Syndrome 1 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a GTPase-activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9ULL6 |
| NCBI GenInfo Identifier: | 186928844 |
| NCBI Gene ID: | 57514 |
| NCBI Accession: | NP_065805.2 |
| UniProt Secondary Accession: | Q9ULL6,Q9ULL6 |
| UniProt Related Accession: | Q9ULL6,Q2M1Z3 |
| Molecular Weight: | 157kd |
| NCBI Full Name: | rho GTPase-activating protein 31 |
| NCBI Synonym Full Names: | Rho GTPase activating protein 31 |
| NCBI Official Symbol: | ARHGAP31 |
| NCBI Official Synonym Symbols: | AOS1; CDGAP |
| NCBI Protein Information: | rho GTPase-activating protein 31 |
| UniProt Protein Name: | Rho GTPase-activating protein 31 |
| UniProt Synonym Protein Names: | Cdc42 GTPase-activating protein |
| Protein Family: | |
| UniProt Gene Name: | ARHGAP31 |
| UniProt Entry Name: | RHG31_HUMAN |
