PCSK9 Polyclonal Antibody (CAB23546)
- SKU:
- CAB23546
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
PCSK9 Polyclonal Antibody (CAB23546)
The PCSK9 Polyclonal Antibody (CAB23546) is a valuable tool for researchers studying PCSK9, a key player in cholesterol metabolism and cardiovascular health. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for a variety of research applications, including Western blot analysis.PCSK9, a proprotein convertase subtilisin/kexin type 9, is involved in the regulation of LDL cholesterol levels by targeting the LDL receptor for degradation. Dysregulation of PCSK9 has been linked to familial hypercholesterolemia and other cardiovascular diseases, making it a promising target for therapeutic interventions.
The PCSK9 Polyclonal Antibody enables researchers to detect and analyze PCSK9 protein expression in various cell types, providing insights into its role in cholesterol metabolism and cardiovascular health.By studying the function and regulation of PCSK9, researchers can gain a better understanding of its implications in cardiovascular diseases and develop potential strategies for therapeutic intervention. The PCSK9 Polyclonal Antibody is a valuable tool for advancing research in the field of lipid metabolism and cardiovascular health.
| Product Name: | PCSK9 Polyclonal Antibody |
| Product Code: | CAB23546 |
| Reactivity: | Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Mouse |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa |
Enables apolipoprotein binding activity; lipoprotein particle binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including cellular response to insulin stimulus; cellular response to starvation; and regulation of neuron apoptotic process. Acts upstream of or within several processes, including low-density lipoprotein receptor particle metabolic process; regulation of low-density lipoprotein particle receptor catabolic process; and triglyceride metabolic process. Located in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; and extracellular space. Is expressed in several structures, including alimentary system; cerebellum; genitourinary system; liver; and telencephalon. Human ortholog(s) of this gene implicated in familial hypercholesterolemia and hypobetalipoproteinemia. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9).
| Immunogen: | Recombinant protein of mouse PCSK9. |
| Sequence: | Email for sequence |
| Synonyms: | FH3, PC9, Narc1, HCHOLA3 |
| Calculated MW: | 74KDa |
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