The NRDD Antibody (PAC033660) is a polyclonal antibody designed for research involving NRDD, a protein associated with DNA damage repair and cell cycle regulation. This antibody, raised in rabbits, is highly specific and reacts with human samples in Western blot applications. It binds to the NRDD protein, allowing for detection and analysis in a variety of cell types, making it an ideal tool for studies in molecular biology and cancer research.NRDD, also known as nucleotide excision repair helicase, is a key player in maintaining genomic stability by repairing DNA damage and ensuring proper cell division.
Its role in DNA repair pathways makes it a promising target for therapies aimed at improving cancer treatments and understanding genetic disorders. Investigating the function of NRDD is essential for developing strategies to enhance DNA damage repair mechanisms and prevent mutations that lead to disease progression.
Antibody Name:
nrdD Antibody (PACO33660)
Antibody SKU:
PACO33660
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Escherichia coli
Immunogen:
Recombinant Escherichia coli Anaerobic ribonucleoside-triphosphate reductase protein (1-712AA)
Ribonucleotide reductase is an essential enzyme in all organisms. It provides precursors for DNA synthesis by reducing all four ribonucleotides to deoxyribonucleotides. The overall activity and the substrate specificity of RNR are allosterically regulated by deoxyribonucleoside triphosphates and ATP, thereby providing balanced dNTP pools.
Synonyms:
Anaerobic ribonucleoside-triphosphate reductase (EC 1.1.98.6) (Class III ribonucleoside-triphosphate reductase), nrdD
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
Activated NrdD is predicted to be cleaved by oxygen at the Gly681 radical, dropping the last 31 aa. [More information is available at EcoGene: EG11417]. The NrdD reductase is activated by the NrdG activase under anaerobic conditions and is inactivated by oxygen. [More information is available at EcoCyc: EG11417].
