Description
| Product Name: | Mouse PTX2 Recombinant Protein |
| Product Code: | RPPB4335 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | PTX2 |
| Synonyms: | Serum amyloid P-component, SAP, Apcs, Sap, Ptx2. |
| Source: | HEK293 Cells |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | PTX2 protein solution (0.25mg/ml) contains 10% glycerol in Phosphate Buffered Saline (pH 7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | QTDLKRKVFV FPRESETDHV KLIPHLEKPL QNFTLCFRTY SDLSRSQSLF SYSVKGRDNE LLIYKEKVGE YSLYIGQSKV TVRGMEEYLS PVHLCTTWES SSGIVEFWVN GKPWVKKSLQ REYTVKAPPS IVLGQEQDNY GGGFQRSQSF VGEFSDLYMW DYVLTPQDIL FVYRDSPVNP NILNWQALNY EINGYVVIRP RVWDHHHHHH |
PTX-2 or Pentraxin-2 is a phylogenetically conserved protein, commonly moving with homopentameric blood protein or with a protein that recognizes receptors of the innate immune system. The protein�s specific binding abilities may show that PTX-2 is specially bound in sites where injury accrued, therefore helps to eliminate damaged tissue by ways that are not phlogistics.
PTX2 Mouse Recombinant produced in�Sf9 Insect cells is a single, glycosylated polypeptide chain containing 210 amino acids (21-224 a.a) and having a molecular mass of 24.6kDa. (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). PTX2 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | APCS: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. Belongs to the pentaxin family.Protein type: Secreted; Secreted, signal peptide; ChaperoneCellular Component: extracellular matrix; extracellular space; protein complex; extracellular region; nucleusMolecular Function: metal ion binding; complement component C1q binding; virion binding; calcium ion binding; carbohydrate bindingBiological Process: negative regulation of virion penetration into host cell; innate immune response; protein complex assembly; negative regulation of monocyte differentiation; negative regulation of viral reproduction |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P12246 |
| NCBI GenInfo Identifier: | 134198 |
| NCBI Gene ID: | 0 |
| NCBI Accession: | P12246.2 |
| UniProt Secondary Accession: | P12246 |
| UniProt Related Accession: | P12246 |
| Molecular Weight: | |
| NCBI Full Name: | Serum amyloid P-component |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Serum amyloid P-component |
| UniProt Synonym Protein Names: | |
| Protein Family: | S-layer protein |
| UniProt Gene Name: | Apcs�� |
| UniProt Entry Name: | SAMP_MOUSE |
