Mouse IL-13 In Vivo Low Endotoxin Antibody [38213] (IVMB0394)

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SKU:
IVMB0394
Antibody Type:
Functional-Grade In Vivo Antibody
Endotoxin Level:
Low Endotoxin
Applications:
In Vivo
Disease Area:
Cancer
Clone:
38213
Reactivity:
Mouse
Host Species:
Rat
Size:
100 µg
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Description

Product Name:Mouse IL-13 In Vivo Low Endotoxin Antibody [38213]
Product Code:IVMB0394
Size:100 µg
Clone:38213
Product Type:Monoclonal Antibody
Synonyms:ALRH, BHR1, MGC116786, P600, NC30, Interleukin-13
Isotype:IgG2a
Reactivity:Mouse
Formulation:This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.4 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Endotoxin Level:<0.1 EU/µg as determined by the LAL method
Host Species:Rat
Specificity:Rat Anti-Mouse Interleukin 13 (IL-13) (Clone 38213) recognizes an epitope on Mouse IL-13. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Immunogen:Purified Recombinant Mouse IL-13 (>98%)
Storage and Handling:The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

Interleukin 13 (IL-13) is a cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells1, that is an important mediator of allergic inflammation and disease. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα), which is also a component of the IL-4 receptor, and at least one of two known IL-13-specific binding chains.1 The functions of IL-13 overlap considerably with those of IL-4. Although IL-13 is associated primarily with the induction of airway disease, it also has anti-inflammatory properties. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.

Research Area: Other Molecules

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