Description
| Product Name: | Mouse BRAK Recombinant Protein |
| Product Code: | RPPB1104 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | BRAK |
| Synonyms: | C-X-C motif chemokine 14, B-cell and monocyte-activating chemokine, Chemokine BRAK, Kidney-expressed chemokine CXC, MIP-2G, Small-inducible cytokine B14, Cxcl14, Bmac, Kec, Ks1, Mip2g, Scyb14, BRAK, NJAC, AI414372, bolekine, MIP2gamma, 1110031L23Rik, 1200006I23Rik. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | CXCL14 was lyophilized from a 0.2�m filtered concentrated solution in 20mM PB, pH 7.4 and 500mM NaCl. |
| Solubility: | It is recommended to reconstitute the lyophilized CXCL14 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized CXCL14 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL14 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIVTTKS MSRYRGQEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE |
| Biological Activity: | The ED50 of CXCL14 as determined by its ability to chemoattract activated monocytes using a concentration range of 1.0-10.0 ng/ml. |
CXCL14 is involved in immunoregulatory and inflammatory processes. BRAK protein is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. CXCL14 displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. CXCL14 is involved in the homeostasis of monocyte-derived macrophages.
CXCL14 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 77 amino acids and having a molecular mass of 9.4kDa.The CXCL14 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CXCL14: Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. Belongs to the intercrine alpha (chemokine CxC) family. |
| UniProt Protein Details: | Protein type:Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 13|13 B1 Cellular Component: extracellular region; extracellular space; Golgi apparatus Molecular Function:chemokine activity; cytokine activity Biological Process: cell-cell signaling; immune response; inner ear development; negative regulation of myoblast differentiation |
| UniProt Code: | Q9WUQ5 |
| NCBI GenInfo Identifier: | 119392098 |
| NCBI Gene ID: | 57266 |
| NCBI Accession: | NP_062514.2 |
| UniProt Secondary Accession: | Q9WUQ5,Q548T5, Q91V02, Q9JHH7, |
| UniProt Related Accession: | Q9WUQ5 |
| Molecular Weight: | 11,716 Da |
| NCBI Full Name: | C-X-C motif chemokine 14 |
| NCBI Synonym Full Names: | chemokine (C-X-C motif) ligand 14 |
| NCBI Official Symbol: | Cxcl14�� |
| NCBI Official Synonym Symbols: | KS1; Kec; BMAC; BRAK; NJAC; MIP-2g; Scyb14; AI414372; bolekine; MIP2gamma; 1110031L23Rik; 1200006I23Rik�� |
| NCBI Protein Information: | C-X-C motif chemokine 14 |
| UniProt Protein Name: | C-X-C motif chemokine 14 |
| UniProt Synonym Protein Names: | B-cell and monocyte-activating chemokine; Chemokine BRAK; Kidney-expressed chemokine CXC; MIP-2G; Small-inducible cytokine B14 |
| UniProt Gene Name: | Cxcl14�� |
