Mouse BD14 Recombinant Protein (RPPB0079)
- SKU:
- RPPB0079
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Mouse
- Target:
- BD14
- Synonyms:
- Beta-defensin 14
- BD-14
- mBD-14
- Defensin
- Source:
- Escherichia Coli
- Uniprot:
- Q7TNV9
Description
| Product Name: | Mouse BD14 Recombinant Protein |
| Product Code: | RPPB0079 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | BD14 |
| Synonyms: | Beta-defensin 14, BD-14, mBD-14, Defensin, beta 14, Defb14. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | BD-14 protein was lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized BD14 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Mouse BD14 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BD-14 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 96.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | FLPKTLRKFF CRIRGGRCAV LNCLGKEEQI GRCSNSGRKC CRKKK |
Alpha and Beta Defensins are cationic peptides with antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi and enveloped viruses. These 2-6kDa proteins have vital roles in innate immune system. Mammalian Defensins are classified into alpha, beta and theta categories, based on their size and pattern of disulfide bonding. Beta-Defensins contain a six-cysteine motif which forms 3 intra-molecular disulfide bonds. Since beta-defensins are cationic peptides, they can therefore interact with the membrane of invading microbes, which are negative due to lipopolysaccharides (LPS) and lipoteichoic acid (LTA) found in the cell membrane. In addition, they can affect the stability of the membrane.
Beta Defensin-14 Mouse Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 45 amino acids and having a molecular mass of 5.2kDa.The BD14 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Has antibacterial activity. |
| UniProt Code: | Q7TNV9 |
| NCBI GenInfo Identifier: | 33942110 |
| NCBI Gene ID: | 244332 |
| NCBI Accession: | NP_898847.1 |
| UniProt Secondary Accession: | Q7TNV9,Q14BD1, |
| UniProt Related Accession: | Q7TNV9 |
| Molecular Weight: | |
| NCBI Full Name: | beta-defensin 14 |
| NCBI Synonym Full Names: | defensin beta 14 |
| NCBI Official Symbol: | Defb14 |
| NCBI Official Synonym Symbols: | BD-14 |
| NCBI Protein Information: | beta-defensin 14 |
| UniProt Protein Name: | Beta-defensin 14 |
| UniProt Synonym Protein Names: | Defensin, beta 14 |
| UniProt Gene Name: | Defb14 |
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