Map2k5 Antibody (PACO21465)
- SKU:
- PACO21465
- Product type:
- Antibody
- Reactivity:
- Human
- Rat
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | Map2k5 Antibody (PACO21465) |
| Antibody SKU: | PACO21465 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000 |
| Species Reactivity: | Human, Rat, Mouse |
| Immunogen: | Peptide sequence around aa. 311-315(K-T-Y-V-G ) derived from Rat MEK5. |
| Form: | Liquid |
| Storage Buffer: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extract from rat brain and mouse brain tissue using MEK5 Antibody. |
| Background: | A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phospho-rylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resem-bles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphory-late ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7)phosphorylates and activates the JNK signal transduction pathway. Jiang, Y., et al. 1996. J. Biol. Chem. 271: 17920-17926. Holland, P.M., et al. 1997. J. Biol. Chem. 272: 24994-24998. |
| Synonyms: | MAP kinase kinase 5; Map2k5; MAPKK 5; MAPK/ERK kinase 5; |
| UniProt Protein Function: | MEK5: a dual specificity protein kinase of the STE7 family. Activates ERK5 and is itself phosphorylated and activated by MEKK3, as well as by atypical protein kinase C isoforms. Involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced isoforms have been described.Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 familyCellular Component: membrane; spindle; intracellular; nucleus; cytosolMolecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; metal ion binding; protein-tyrosine kinase activity; ATP binding; protein kinase activityBiological Process: peptidyl-tyrosine phosphorylation; negative regulation of heterotypic cell-cell adhesion; activation of MAPK activity; heart development; MAPKKK cascade; negative regulation of interleukin-8 biosynthetic process; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; positive regulation of protein metabolic process; positive regulation of cell growth; inhibition of NF-kappaB transcription factor; positive regulation of transcription from RNA polymerase II promoter; positive regulation of epithelial cell proliferation |
| UniProt Protein Details: | |
| NCBI Summary: | kinase involved in signal transduction in the cell [RGD, Feb 2006] |
| UniProt Code: | Q62862 |
| NCBI GenInfo Identifier: | 2499634 |
| NCBI Gene ID: | 29568 |
| NCBI Accession: | Q62862.1 |
| UniProt Secondary Accession: | Q62862,Q62863, Q62864 |
| UniProt Related Accession: | Q62862 |
| Molecular Weight: | 448 |
| NCBI Full Name: | Dual specificity mitogen-activated protein kinase kinase 5 |
| NCBI Synonym Full Names: | mitogen activated protein kinase kinase 5 |
| NCBI Official Symbol: | Map2k5 |
| NCBI Official Synonym Symbols: | Mek5 |
| NCBI Protein Information: | dual specificity mitogen-activated protein kinase kinase 5; MEK 5; MAPKK 5; MAPK/ERK kinase 5; MAP kinase kinase 5 |
| UniProt Protein Name: | Dual specificity mitogen-activated protein kinase kinase 5 |
| UniProt Synonym Protein Names: | MAPK/ERK kinase 5; MEK 5 |
| Protein Family: | Dual specificity mitogen-activated protein kinase kinase |
| UniProt Gene Name: | Map2k5 |
| UniProt Entry Name: | MP2K5_RAT |
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