LAMC2 Rabbit Polyclonal Antibody (CAB1869)

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SKU:
CAB1869
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Frequently bought together:

Description

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LAMC2 Rabbit Polyclonal Antibody (CAB1869)

The LAMC2 Polyclonal Antibody (CAB1869) is a valuable tool for researchers studying LAMC2, a protein component of laminin, an essential extracellular matrix protein involved in cell adhesion and migration. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blotting applications.LAMC2 is known to play a critical role in various physiological processes, including cell differentiation, tissue development, and wound healing.

Aberrant expression of LAMC2 has been linked to several pathological conditions, such as cancer metastasis and tissue fibrosis.By targeting the LAMC2 protein, researchers can better understand its functions and implications in disease pathogenesis. The use of the LAMC2 Polyclonal Antibody in experiments can enable detection and analysis of LAMC2 in different cell types and tissues, making it a valuable tool for studies in cancer biology, tissue remodeling, and development.

Product Name:LAMC2 Rabbit Polyclonal Antibody
SKU:CAB1869
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 746-860 of human LAMC2 (NP_005553.2).
Sequence:DHYV GPNG FKSL AQEA TRLA ESHV ESAS NMEQ LTRE TEDY SKQA LSLV RKAL HEGV GSGS GSPD GAVV QGLV EKLE KTKS LAQQ LTRE ATQA EIEA DRSY QHSL RLLD SVSR LQG
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:1000 - 1:5000 IF/ICC,1:50 - 1:100
Synonyms:B2T; CSF; EBR2; BM600; EBR2A; JEB3A; JEB3B; LAMB2T; LAMNB2; LAMC2
Positive Sample:A-431,K-562
Conjugate:Unconjugated
Cellular Localization:Secreted, basement membrane, extracellular matrix, extracellular space.
Calculated MW:131kDa
Observed MW:150kDa

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney.The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction.

Purification Method:Affinity purification
Gene ID:3918
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates, using LAMC2 Rabbit pAb (CAB1869) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

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