The KCTD6 Polyclonal Antibody (PAC038314) is a valuable tool for researchers studying KCTD6, a protein involved in various cellular processes, including gene transcription and protein ubiquitination. This antibody, produced in rabbits, exhibits high specificity for KCTD6 in human samples and is suitable for use in Western blot applications. By targeting the KCTD6 protein, this antibody allows for the detection and analysis of KCTD6 expression in different cell types, making it ideal for investigations in molecular biology and cell signaling pathways.
KCTD6, a member of the potassium channel tetramerization domain-containing (KCTD) protein family, is known to interact with diverse proteins and play a role in multiple biological pathways. It has been implicated in regulating neuronal development, synaptic plasticity, and cell proliferation, making it a promising target for research in neurobiology and cancer biology. By studying the function of KCTD6, researchers can gain insights into its role in disease processes and potentially develop targeted therapeutic strategies in the future.
Antibody Name:
KCTD6 Antibody (PACO38314)
Antibody SKU:
PACO38314
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA)
Immunohistochemistry of paraffin-embedded human lung tissue using PACO38314 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO38314 at dilution of 1:100.
Background:
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation.
Synonyms:
BTB/POZ domain-containing protein KCTD6 (KCASH3 protein) (Potassium channel tetramerization domain-containing protein 6), KCTD6
UniProt Protein Function:
KCTD6: Protein type: Unknown functionChromosomal Location of Human Ortholog: 3p14.3Molecular Function: ankyrin binding; protein binding
